实用医学杂志Issue(11)：1755-1758,4.DOI:10.3969/j.issn.1006-5725.2015.11.008
他达拉非延缓大鼠慢性移植血管硬化病变
Tadalafil attenuates chronic allograft vasculopathy in rat
摘要
Abstract
Objective To evaluate the effects of tadalafil on chronic allograft vasculopathy. Method The abdominal aorta transplantation was performed on Male Lewis or Brown-Norwai rats as donors and male Male Lewis rats as recipients. The recipients were divided into 3 groups: Group A (Lewis-Lewis)with no treatment ;Group B (BN-Lewis) with no treatment; Group C (BN-Lewis) received tadalafil treatment (0.5 mg/kg per day). The rats were sacrificed at 8 weeks post treatment. The grafted aortas were used for histology and Western blot assay. Plasma cGMP level was detected by ELISA assay. Results The aortas intimal in group C was significantly thinner than that in group B. PKG-Ⅰprotein expression in group C was significantly higher than that in group B. Expression of RhoA in group C was lower than that in group B. Conclusion Tadalafil has positive effect on chronic allograft vasculopathy.关键词
他达拉非/移植物闭塞/移植Key words
Tadalafil/Graft Occlusion/Transplantation引用本文复制引用
徐自强,夏鹏,王瑾珺,金昊,杨亦荣..他达拉非延缓大鼠慢性移植血管硬化病变[J].实用医学杂志,2015,(11):1755-1758,4.基金项目
浙江省教育厅基金资助项目（编号Y201326684）；温州市科技计划资助项目（编号Y20120157）；浙江省科技厅实验动物平台项目 （）
