实用医学杂志Issue(11)：1790-1793,4.DOI:10.3969/j.issn.1006-5725.2015.11.020
尿微量白蛋白／肾小球滤过率与对比剂肾病发生的相关性
Relationship between microalbuminuria to estimated glomerular filtration rate ratio and incidence of contrast induced nephropathy
乔平 1曾和松 2黄芬 2贺行魏2
作者信息
- 1. 570311 海口市，海南省人民医院心内科
- 2. 430030 武汉市，华中科技大学同济医学院附属同济医院心血管内科
- 折叠
摘要
Abstract
Objective To investigate the relationship between microalbuminuria to estimated glomerular filtration rate (mALB/GFR) ratio and incidence of contrast induced nephropathy (CIN) after underwent percutaneous coronary intervention (PCI). Between March 2010 to August 2011, a total of 137 patients who underwent PCI were selected. Anthropometric measures, lipid profiles, fasting blood glucose, CRP, base creatinine and microalbuminuria were measured before operation. Glomerular filtration rate was calculated by MDRD formula. Contrast volume (CV) was recorded after the operation for each patient. Serum creatinine was measured 24 h, 48 h, 72 h after operation, respectively. CIN was defined as an increase in serum creatinine levels of 25% or 44 μmol/L or more from baseline within 72 h after PCI. All patients were divided into group A (CIN group) and group B (No CIN group). Results Eighteen (13.1%) patients developed CIN(group A). The others were group B (no CIN group). The level of CRP, base creatinine, microalbuminuria and mALB/GFR in group A were significantly higher than that in group B ( P < 0 . 01 ) . GFR in group A was lower than that in group B (P < 0.05). Logistic regression analysis indicated that the level of base creatinine , microalbuminuria GFR and mALB/GFR were independent risk factors of CIN occurrence (P < 0.05). The receiver-operator characteristic curve analysis indicated that a mALB/ GFR ratio of 1.17 was a fair discriminator for CIN,and sensitivity were 94.1%, specifity were 72.5%. Conclusion A mALB/ GFR ratio was a independent predictor of CIN after PCI.关键词
尿微量白蛋白/肾小球滤过率/对比剂肾病/冠状动脉介入治疗Key words
Microalbuminuria/Glomerular filtration rate/Contrast induced nephropathy/Percutaneous coronary interrention引用本文复制引用
乔平,曾和松,黄芬,贺行魏..尿微量白蛋白／肾小球滤过率与对比剂肾病发生的相关性[J].实用医学杂志,2015,(11):1790-1793,4.
