特产研究Issue(2)：9-11,22,4.
星点设计－效应面法优化葛根黄酮固体脂质纳米粒处方
Optimization of the Formula for Puerarin Flavonoids Solid Lipid Nanoparticle by Central Design-Response Surface Method
摘要
Abstract
Central design-response surface method was employed to optimize the formula of puerarin flavonoids solid lipid nanoparticle (PF-SLN ) .Dosages of stearic acid ,poloxamer 188 and soybean lecithin were chosen as independent variables ,entrapment efficiency was selected as dependent variable solvent ,injection method was used to prepare PF-SLN .The results showed that binomial fitting equations of indexes were all superior to that of multi-linear regression equations .The optimal dosage of stearic acid ,poloxamer 188 and soybean lecithin were 0.50g-0.65g ,0.125g-0.14g ,0.25g-0.45g respectivel .The predictive values of entrapment efficiency were in conformity with the experimental val-ues well .关键词
葛根黄酮/星点设计/固体脂质纳米粒Key words
puerariaflavonoids/central composite design/solid lipid nanoparticle分类
医药卫生引用本文复制引用
张广远,孙士淋,刘昕,樊红波,王玉,管清香..星点设计－效应面法优化葛根黄酮固体脂质纳米粒处方[J].特产研究,2015,(2):9-11,22,4.基金项目
吉林省科技厅项目（20130206049YY ）；吉林省中医药管理局项目 （）
