同位素Issue(4)：223-229,7.DOI:10.7538/tws.2014.27.04.0223
18F标记的新型鏻正阳离子 PET 心肌灌注显像剂的制备及生物性能评价
Preparation and Biological Evaluation of Novel 18 F-labeled Phosphonuim Cation for Myocardial Perfusion Imaging with PET
摘要
Abstract
In order to develop new PET myocardial perfusion imaging agent ,a novel 18 F labeled phosphonium cation :(3‐([18 F]fluoromethyl)benzyl) tris (2 ,6‐dimethoxyphe‐nyl) phosphonium salt ,18 F‐2 ,had been designed and prepared .Biological evaluation of 18 F‐2 had been performed in Kunming normal mice .18 F‐2 was obtained by a simple one‐pot method and the radiochemical yield was (31 ± 3)% .The total radio‐synthesis time was less than 60 min and the radiochemical purity of final radiotracer was more than 95% .The biodistribution of 18 F‐2 displayed a high heart uptake and good retention . The heart uptake of 18 F‐2 at 5 and 60 min post‐injection were (53.88 ± 7.45)% ID/g and (23.93 ± 3.28)% ID/g ,respectively .18F‐2 exhibited low radio‐accumulation in non‐target tissues and rapid clearance in liver ,lung and blood .The heart to liver ,heart to lungs and heart to blood ratio values were 3.99 ,3.80 and 9.17 ,respectively .The results indicated that 18 F‐2 could be as a promising myocardial perfusion imaging agent for PET imaging .关键词
18F标记/鏻正阳离子/心肌灌注显像剂Key words
18 F labeled/phosphonium cation/myocardial perfusion imaging agent分类
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彭程,赵祚全,陈淑婷,马云川,张现忠,陆洁..18F标记的新型鏻正阳离子 PET 心肌灌注显像剂的制备及生物性能评价[J].同位素,2014,(4):223-229,7.基金项目
国家自然科学基金项目 （）
