同位素Issue(4)：230-235,6.DOI:10.7538/tws.2014.27.04.0230
自动化合成11C-Raclopride 及质量控制
Automatic Synthesis and Quality Control of 11 C-Raclopride for Clinical Use
摘要
Abstract
Automatic synthesis of 11 C‐Raclopride was used for routinely clinical imaging with home‐made C‐11 synthesized module .METHODS :11C‐Triflate‐CH3 was bubbled through a vial at room temperature , containing a acetone solution of precursor and NaOH . The reaction solution was transferred to Semi‐HPLC for purification . The crude production was purified by C‐18 Solid‐Extraction‐Purification (SEP) .The injec‐tion solution was formatted by 1mL alcohol eluated from the SEP‐C‐18 ,the eluated sol‐uation was diluted with saline to less 10% of alcohol .RESULTE :The amount of base leaded to increase the yields of by‐production of C‐N methlyation .The synthesis yield was (55.1 ± 8.4)% (n=40) with precursor of 0.1 to 0.4 mg ,and had no relationship with NaOH in 1 μmol to 50 μmol .It took 28 min from 11CO2 to obtain 11C‐Raclopride injection solution .The radiochemical purity was over 99% .The radiochemical concen‐tration was 370 to 550 MBq/mL at specific activity of 1.73 × 1014 Bq/g .The injection solution was proved to be sterile and pyrogen free .CONCLUSION :11C‐Raclopride was automatic synthesized from 11CH3‐Triflate with home‐made C‐11 synthesizer module . The quality and quantity of 11C‐Raclopride injection solution was confirmed to be suit‐able for clinical PET imaging .关键词
雷氯必利/自动化合成/质量控制Key words
raclopride/automatic synthesis/quality control分类
化学化工引用本文复制引用
张锦明,张晓军,李云钢,刘健,徐白萱,王瑞民,田嘉禾..自动化合成11C-Raclopride 及质量控制[J].同位素,2014,(4):230-235,6.基金项目
军队医疗机构制剂标准提高项目 （）
