同位素Issue(2)：107-112,6.DOI:10.7538/tws.2015.28.02.0107
125I-rAncrod 在大鼠体内的组织分布与代谢
Tissue Distribution and Metabolism of 125 I-rAncrod in Wistar Rats
于秋菊 1窦桂芳 2朱晓霞 3王德才 3孟志云 1甘慧 3顾若兰 3吴卓娜 3郑颖 3李俭3
作者信息
- 1. 泰山医学院，山东 泰安 271000
- 2. 军事医学科学院 野战输血研究所，北京 100850
- 3. 军事医学科学院 野战输血研究所，北京 100850
- 折叠
摘要
Abstract
To study the tissue distribution and metabolism of radioactivity in rats after single intravenous administration of 125 I‐rAncrod(1.59μg · kg -1 ) .The concentration of 125 I‐rAncrod in various tissue and body fluids were determined by 125 I labeled rAncrod combined with size exclusion chromatography (SEC) andγ‐counting methods .The con‐centration of 125 I‐rAncrod predominantly accumulated in the thyroid and gastrointestinal and also be found in the kidney and liver in fair amounts ,but in brain ,spinal cord , muscle and fat was at a very low level .After single intravenous administration (chemi‐cal dose 1.59 μg · kg -1 ) of 125 I‐rAncrod to Wistar rats ,the samples of feces ,urine and bile were analyzed by SEC .The result was that parent drug was not existed in feces , urine and bile in 48 h .The results showed that 125 I‐rAncrod was distributed widely in rats ,metabolic process was complete .关键词
125 I标记重组安克洛酶/组织分布/代谢Key words
125 I-rAncrod/tissue distribution/metabolism分类
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于秋菊,窦桂芳,朱晓霞,王德才,孟志云,甘慧,顾若兰,吴卓娜,郑颖,李俭..125I-rAncrod 在大鼠体内的组织分布与代谢[J].同位素,2015,(2):107-112,6.
