武警医学Issue(11)：1085-1088,4.
IL-6基因启动子区-634 C／G 多态性与糖尿病视网膜病变的关系
Association of IL-6 gene promoter region -643 C/G polymorphism with diabetic retinopa-thy
摘要
Abstract
Objective To investigate the association of IL-6 gene promoter region -643C/G polymorphism with diabetic reti-nopathy .Methods The polymorphism of IL-6 gene promoter region -634 C/G in 245 unrelated Guangdong Han people with type 2 di-abetes ,including 153 cases without diabetic retinopathy (DR0 group) ,51 cases without proliferative diabetic retinopathy (NPDR) (DR1 group), 41 cases with proliferative diabetic retinopathy (PDR) (DR2 group), and 101 normal controls(NC group) were detec-ted by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP) methods .The genotype frequency , allele fre-quency and relative clinical data were compared between groups .Results ( 1 ) There were no significant differences in the clinical characteristics except for diabetic duration among DR 0, DR1, DR2 groups.(2) The frequencies of IL-6-643 G/G genotype and G al-lele frequencies among DR0 DR1 DR2 groups were statistically different .There were significantly different in GG genotype between DR0 and DR group,comparison between any two means were not significant differences in G allele frequencies .(3) Logistic regression analysis showed that IL-6 gene promoter region-643G/G genotype,fasting plasma glucose and diabetic duration were risk factors of DR . Conclusions The IL-6 promoter region-643G/G genotype may be a genetic risk factor of DR development .关键词
白细胞介素-6基因/启动子区/多态性/糖尿病视网膜病变Key words
IL-6 gene/promoter region/polymorphism/diabetic retinopathy分类
医药卫生引用本文复制引用
安新焕,梁干雄,武会娟..IL-6基因启动子区-634 C／G 多态性与糖尿病视网膜病变的关系[J].武警医学,2014,(11):1085-1088,4.基金项目
广东省中山市科技局基金资助项目 （）
