武警医学Issue(11)：1131-1134,4.
高压氧干预对大鼠创伤性脑损伤后脑组织NF-κB（p50）表达的影响
Effect of hyperbaric oxygenation treatment on expression of NF-κB p50 in the rat brain tissue after traumatic brain injury
杨柏林 1王欢 1彭军 1徐其明 1余超1
作者信息
- 1. 330030 南昌，武警江西总队医院神经外科
- 折叠
摘要
Abstract
Objective To observe the effect of hyperbaric oxygenation treatment ( HBOT) on expression of NF-κB( p50) in the rat brain tissue after traumatic brain injury ( TBI) and discuss its mechanism .Methods Thirty-five Sprague-Dawley rats were divided into sham operation control group(5 rats), TBI group(15 rats) and HBOT group(15 rats).Based on the Feeney’s model of modified Allen’s method, experimental animals were treated with HBOT .The animals were sacrificed at the 8th hour, and on days 1,3,5,8,re-spectively.The expression of protein NF-κB was determined by Westernblotting .Results The expression of NF-κB was significantly higher in traumatic group than that in control group at the time of 8 hour and 1,3,5and 8 days after injury (P<0.05).The level of NF-κB reached peak on the 3th day, and maintained a high status from 5 to 8 days.Compared with traumatic group, the NF-κB level was significantly lower in the HBOT group (P<0.05).Conclusion HBOT can weaken NF-κB expression in traumatic brain tissue and inhibit effectively inflammatory response , which provides theoretical basis for treating severe traumatic brain injury .关键词
重型颅脑损伤/高压氧/大鼠/NF-κBKey words
severe brain injury/hyperbaric oxygenation/rats/NF-κB分类
医药卫生引用本文复制引用
杨柏林,王欢,彭军,徐其明,余超..高压氧干预对大鼠创伤性脑损伤后脑组织NF-κB（p50）表达的影响[J].武警医学,2014,(11):1131-1134,4.
