武警医学Issue(1)：75-78,4.
黄芩苷与红景天胶囊对急性高原病预防作用比较
Effect of baicalin capsules on acute mountain sickness in healthy young males at acute high altitude exposure
摘要
Abstract
Objective To investigate the effect of baicalin capsules for acute mountain sickness ( AMS) prevention with rapid airlift ascent to high altitude .Methods A randomized controlled trial was conducted on 80 healthy young men with baicalin capsules (0.5 g bid, n=32), rhodiola capsules (0.76 g bid, n=24), or placebo (n=24), for 2 days prior to airlift ascent (397 m) and for the first 3 days at high altitude (3658 m).AMS, oxygen saturation (SpO2), heart rate (HR), systolic blood pressure(SBP), diastolic blood pressure ( DBP) , pulmonary artery systolic pressure ( PASP) and mean pulmonary arterial pressure ( MPAP) were assessed both at 397 m and 3658 m.Results After high-altitude exposure, significantly fewer participants in the baicalin capsules group (n=8, 25.0%) and rhodiola capsules group(n=7, 29.2%) developed acute mountain sickness compared with participants receiving placebo (n=14, 58.3%) (P<0.05) .HR, SBP, DBP, PASP and MPAP increased with altitude exposure (P<0.05), and SpO2 decreased with alti-tude exposure (P<0.05).AMS, HR, SBP and DBP with baicalin capsules was lower than those with placebo (P<0.05); AMS, PASP, MPAP with rhodiola capsules were lower than those with placebo (P<0.05) and SpO2 was higher than that with placebo (P<0.05).Conclusions Baicalin capsules for AMS prevention also reduce HR , SBP and DBP with rapid airlift ascent to high altitude and rhodiola capsules for AMS prevention also reduce PASP , MPAP, increase SpO2 with rapid airlift ascent to high altitude .关键词
急性高原病/黄芩苷胶囊/红景天胶囊/血压/肺动脉压Key words
acute mountain sickness/baicalin capsules/rhodiola capsules/blood pressure/pulmonary artery systolic pressure分类
医药卫生引用本文复制引用
段炜,孙书红,惠增骞,高钊,胡建库,金峰,陈虹..黄芩苷与红景天胶囊对急性高原病预防作用比较[J].武警医学,2015,(1):75-78,4.基金项目
武警部队后勤部2012年科研项目 （）
