摘要
Abstract
Objective To investigate the protective effect of total flavones of Artemisia capillaris Thumb on chronic liver injury induced by subcutaneous injection of CCl 4 continually in rats.Methods The rats in experiment were divided into 6 groups as follows:normal control group (0.9%sodium chloride), model group, positive group (Yinzhihuang oral solution group), low, middle, and high dosage groups of total flavones of Artemisia capillaris Thunb .Body weight and survival rate of rats were determined .The serum sample and the liver tissue samples from all groups were collected for the biochemical and pathological examination , respectively.Results Ani-mal serum ALT in high dose group of Artemisia capillaris Thumb flavones extract was (2659.8 ±923.8) nmol/(s· L).It was significant-ly lower when compared with the model group (6274.3 ±2018.3) nmol/(s· L).Serum ALT activity decreased with increasing doses of Artemisia capillaris Thumb flavones extract .Serum AST had same tendency as serum ALT .Compared with model group , concentration of total protein and albumin increased in the group of Artemisia capillaris Thumb flavones extract .Liver tissue pathology score reduced to va-rying degrees (P<0.01).The score in high dose group was 1.92 ±0.79 and it was much lower than that in model group (3.86 ± 0.43).In addition, Artemisia capillaris Thumb flavones extract can also reduce the liver hydroxyproline content and inhibit liver fibrosis . Conclusions The total flavones of Artemisia capillaris Thumb are effective in protecting the chronic liver injury induced by CCl 4 in rats.关键词
茵陈总黄酮/慢性肝损伤/CCl4/肝保护Key words
total flavones of Artemisia capillaris thumb/chronic liver injury/carbon tetrachloride/hepatoprotective effect分类
药学
