武警医学Issue(3)：244-247,4.
肝动脉化疗栓塞术联合CT引导下射频消融治疗大肝癌的疗效和安全性
TACE combined with CT guided percutaneous radiofrequency ablation for large liver car-cinoma
吴斌 1徐大伟 1王立军 1金文辉 1周文华 1孟亮亮1
作者信息
摘要
Abstract
Objective To evaluate the efficacy and the application value of TACE combined with CT guided percutaneous ra-diofrequency ablation in the treatment of large hepatocellular carcinoma.Methods A retrospective analysis was made on clinical data of 52 patients proved by pathology and imaging diagnosis of hepatocellular carcinoma.All the patients received one TACE treatment, and were reexamined by contrast-enhanced CT two weeks thereafter.Then radiofrequency ablation was performed on the region lacking lipiodol deposition under CT guidance.Postoperatively, all the patients were reexamined by alpha fetoprotein, contrast-enhanced MRI or CT to evaluate the volume reduction and necrosis of tumors and were followed up for 12 months.Results The operations on all 52 patients (56 lesions) were successful without serious complications.The volumes of tumors decreased to varying degrees compared with the preoperative ones.The maximum of the diameters of the focuses was (12.7 ±2.7) cm before TACE, and the maximum of the di-ameters of the focuses was (6.1 ±1.9) cm after the RF ablation operations (t=14.416, P<0.05).The AFP values decreased sig-nificantly, with the AFP value before TACE being (4156 ±689) ng/ml and the AFP value after the RF ablation operations being (256 ±178) ng/ml (t=39.485, P<0.05).Complete ablation (CR) was found in 26 cases, ablation in the majority (PR) was found in 21 cases, 4 cases were found to be stable (SD), progress (PD) was found in 1 case, and the total effective rate was 90.4%.The 12 months survival rate was 92.3%.Conclusions TACE combined with CT guided percutaneous radiofrequency ablation is safe, effec-tive and minimally invasive in the treatment of large hepatocellular carcinoma.关键词
CT引导/射频消融/肝动脉化疗栓塞术/肝癌Key words
CT Guided/radiofrequency ablation/transcatheter arterial chemoembolization/liver carcinoma分类
医药卫生引用本文复制引用
吴斌,徐大伟,王立军,金文辉,周文华,孟亮亮..肝动脉化疗栓塞术联合CT引导下射频消融治疗大肝癌的疗效和安全性[J].武警医学,2015,(3):244-247,4.
