武警医学Issue(3)：273-275,279,4.
雌激素受体阴性乳腺癌中神经胶质瘤致病因子1、基质金属蛋白酶-9的表达及其临床意义
Expression of Gli1, MMP-9 in estrogen-independent breast cancer and its clinical signifi-cance
周育宏 1黄海林 1杜哲明 1陈超 1王学闽 1曾朋1
作者信息
- 1. 330030 南昌，武警江西总队医院普外科
- 折叠
摘要
Abstract
Objective To study the expression and clinical significance of glioma-associated oncogene homolog 1 (Gli1) and matrix metalloproteinases-9 ( MMP-9) in estrogen-independent breast cancer.Methods The expression of Gli1 protein was examined by Envision immunohistochemistry, Gli1, MMP-9 and CD34 expression were examined in ER-negative breast cancer.The relationships between them and CD34, tumor size, TNM stages, lymph node metastasis, HER-2 expression in ER-negative breast cancer were ana-lyzed.Results The expression of CD34 was enhanced by the expression of Gli1 and MMP-9 in ER-negative group( CD34 expression were 48.83 ±7.53,60.69 ±10.02,64.68 ±12.92,75.91 ±11.30 in different group of Gli1;CD34 expressions were 48.15 ±8.44, 61.69 ±10.71,67.76 ±14.03,73.11 ±12.78 in different group of MMP-9), with significant differences (P<0.05).The expression of Gli1 and MMP-9 were correlated with tumor size and clinical TNM stages in ER-negative breast cancer (P<0.05).The expression of MMP-9 was also correlated with lymphatic metastasis (P<0.05).The correlation existed between the expression of Gli1 and MMP-9 in ER-negative breast cancer(r=0.462, P<0.01).Conclusions Clinical positive correlation exists between the expression of Gli1 and MMP-9, Gli1 is an important regulating point in estrogen-independent breast cancer growth way.关键词
乳腺肿瘤/雌激素受体/免疫组织化学/Gli1/基质金属蛋白酶-9Key words
breast cancer/estrogen receptor/immunohistochemistry/Gli1/matrix metalloproteinases-9分类
医药卫生引用本文复制引用
周育宏,黄海林,杜哲明,陈超,王学闽,曾朋..雌激素受体阴性乳腺癌中神经胶质瘤致病因子1、基质金属蛋白酶-9的表达及其临床意义[J].武警医学,2015,(3):273-275,279,4.
