武警医学Issue(5)：444-445,448,3.
血浆尾加压素Ⅱ在慢性阻塞性肺疾病的表达及其意义
Expression and implication of plasma urotensin Ⅱin chronic obstructive pulmonary dis-ease patients
摘要
Abstract
Objective To observe the expression of plasma urotensinⅡ( UⅡ) in the patients with chronic obstructive pulmo-nary disease( COPD) , and to investigate the implication of UⅡ in the pathogenesis and progress of COPD.Methods Patients with COPD including the acute exacerbated COPD and the stable COPD and the healthy control subjects were recruited, Plasma UⅡ con-centration was measured by ELISA.The patients should undergo some exam inations, such as the pulmonary function, complete blood count,bloodgas.SAS6.12 statistical software was used to analyze the data.Results Plasma UⅡshowed a higher expression in acute exacerbated COPD patients than these in stable COPD patients,both highter than in the control subjects and there was statistical signifi-cance(P<0.01).and it was correlated negatively with FEV1.0%、FEV1.0/FVC%、PaO2.Conclusions The concentration of UⅡhas a trend of increase with the deteriorated change of COPD,and may play an important role in the pathogenic process of COPD,such as hypoxia, airway obstruction and inflammation.关键词
慢性阻塞性肺疾病/尾加压素Ⅱ/缺氧/气道阻塞Key words
chronic obstructive pulmonary disease/urotensinⅡ/hypoxia/airway obstruction分类
医药卫生引用本文复制引用
苏宪灵,解立新..血浆尾加压素Ⅱ在慢性阻塞性肺疾病的表达及其意义[J].武警医学,2015,(5):444-445,448,3.基金项目
首都医学发展科研基金 （）
