摘要
Abstract
Objective To investigate the relationship epidermal growth factor receptor ( epidermal growth factor receptor, EG-FR) mutation status and thyroid transcription factor-1 (thyroid transcription factor-1, TTF-1) between the expression and clinical path-ological characteristics in the lung cancer.Methods From 40 patients of operatively resected lung cancer specimens were collected. Using amplification refractory pre system ( ARMS) and polymerase chain reaction ( PCR) , mutation of EGFR gene in lung cancer tissue was detected.Histological typingwas according to the 2011 WHO classification operation specimens.The analysis of relationship between EGFR mutation and TTF-1 expression and clinical pathological characteristics in the lung cancers was analyzed using the statistical soft-ware of SPSS17.0.Results In 40 patients with lung cancer, EGFR gene mutation probability was 57.5%(23/40).EGFR gene muta-tion related to lung cancer patient’s sex, smoking history, lung cancer’s subtype and TTF-1 expression (P<0.05).Conclusions In lung cancer, EGFR gene mutation status is related to TTF-1 expression and histological type, gender, history of smoking.Thewomenwith strong expression of TTF-1,without smoking history and adeno-carcinoma patients have the higher EGFR mutation rate.关键词
肺癌/表皮生长因子受体/甲状腺转录因子/病理学特征Key words
lung cancer/epidermal growth factor receptor/thyroid transcription factor-1/clinical characteristics分类
医药卫生
