摘要
Abstract
Objective To evaluate the biomechanical properties of bovine pericardium ( BP) after posterior sclera reinforce-ment operation ( PSR) ,and to investigate the mechanism of PSR further in the experimental animal and to provide reference for further clinical test and application.Methods Forty-eight New Zealand albino rabbits, weighing 2.2 to 2.5 kg, underwent posterior sclera reinforcement operation of the left eye.All eyes were examined preoperatively by slit lamp biomicroscopy and indirect ophthalmoscopy, and only healthy eyes were included in the experiment.Animals were randomized into 4 groups.For each group, one type of material was surgically implanted at the back of the globe.Group A: uncrosslinked BP ( UBP ) group, 12 rabbits; group B: moderate crosslinked BP MBP group, 12 rabbits.Group C:high crosslinked BP HBP group, 12 rabbits.Group D:human sclera group, 12 rab-bits.The eyes were enucleated at the 2nd, 4th, 12th and 24th week after surgery respectively.The mechanic properties of four groups were evaluated by the BOSS ElectroForce BioDynamic test instruments.Results The patches in group A and D degraded with time and degraded mostly at the time of 24th week after surgery.The patches were intact in group B and C.Statistically significant differ-ence in modulus of elasticity of implanted area of sclera samples was noticed between the time of 4th, 12th week and 2nd week after surgery in group A and D, and the stiffness and breaking strength decreased with time.The modulus of elasticity of implanted area of sclera in group B and C decreased at the 24th week after surgery, the stiffness decreased at the 12th and 24th week after surgery, espe-cially at the time of 24th week.Statistically significant difference in stiffness and breaking strength was noticed between groups A, D and groups B, C at the time of 24th week after surgery.Conclusions The study revealed that MBP and HBP effectively enhances the anti-deformation capacity of the posterior sclera in rabbits and surpasses the BP without crosslink and human sclera .The MBP and HBP may add to our repertoire in preventing the development of progressive myopia.关键词
牛心包/交联/生物力学/后巩膜加固Key words
Bovine pericardium/crosslink/Rabbits/Biomechanics/Scleroplasty分类
医药卫生
