外科理论与实践Issue(3)：232-235,4.DOI:10.16139/j.1007-9610.2015.03.013
结肠癌肝转移机制的研究
Study on mechanism of liver metastasis of colon cancer
蒋春晖 1周全博 1孙隆慈 1顾磊 1徐庆 1罗蒙 1吴志勇 1周鸿1
作者信息
- 1. 上海交通大学医学院附属仁济医院 胃肠外科，上海 200127
- 折叠
摘要
Abstract
Objective To study the possible mechanism of liver metastasis of colon cancer. Methods The liver metastasis model of colon cancer in the rat was induced by injection of murine colon carcinoma cells in spleen. There were normal group, portal branch ligation group, portal vein ligation group and the group of liver cirrhosis induced by CCl4 in this study. The incidence of liver metastasis, portal pressure (PP), alanine aminotransferase of plasma (ALT), hepatocyte growth factor (HGF) and epidermal growth factor (EGF) were analyzed. Results Both PP and plasma ALT levels was not related to liver metastasis incidence. The levels of liver HGF and EGF, however, were closely related to the incidence of liver metastasis. Conclusions There are many factors that affect the liver metastases of colon cancer, including HGF and EGF in addition to PP.关键词
结肠癌肝转移/肝细胞生长因子/表皮生长因子/门静脉压力Key words
Liver metastasis of colon cancer/Hepatocyte growth factor/Epidermal growth factor/Portal pressure分类
医药卫生引用本文复制引用
蒋春晖,周全博,孙隆慈,顾磊,徐庆,罗蒙,吴志勇,周鸿..结肠癌肝转移机制的研究[J].外科理论与实践,2015,(3):232-235,4.
