物理化学学报Issue(7)：1359-1364,6.DOI:10.3866/PKU.WHXB201504131
利用烷基糖苷迁移和扩张共轭亚油酸囊泡pH窗口
Influence of Alkyl Polyglucoside on Migration and Extension of pH Window for Forming Fatty Acid Vesicles of Conjugated Linoleic Acid
摘要
Abstract
Fatty acid vesicles (FAVs) have hol ow core-shel structures similar to those of liposomes, and the building block fatty acids are natural y abundant, green, and safe;therefore, FAVs have potential applications in embedding/release systems. However, FAVs are pH sensitive, and the pH window for FAV formation is narrow and biologically unsuitable. These disadvantages prevent FAVs from being used in domestic chemicals and external y applied agents. In this study, a green and safe nonionic surfactant, alkyl polyglucoside (APG), was blended with a model fatty acid conjugated linoleic acid (CLA) to help the latter to form FAVs in a biological y suitable pH window. The experimental results showed that mixing CLA with APG changed the pH window from 8.0-9.0 for CLA to 6.0-8.0 for CLA-APG;this matches the biological y suitable pH range. Methods for improving the pH dependence of FAV formation and the pH-sensitive properties of FAVs were investigated.关键词
脂肪酸囊泡/pH窗口/共轭亚油酸/烷基糖苷Key words
Fatty acid vesicle/pH window/Conjugated linoleic acid/Alkyl polyglucoside分类
化学化工引用本文复制引用
马洁,樊晔,方云..利用烷基糖苷迁移和扩张共轭亚油酸囊泡pH窗口[J].物理化学学报,2015,(7):1359-1364,6.基金项目
The project was supported by the National Natural Science Foundation of China (21276113).国家自然科学基金(21276113)资助项目 （21276113）
