西安交通大学学报（医学版）Issue(2)：153-158,6.DOI:10.7652/jdyxb201502002
真菌密度感应分子 Farnesol 在表皮葡萄球菌和白假丝酵母菌混合生物膜形成中的作用
The function of Farnesol in formation of Staphylococcus epidermidis-Candida albicans mixed species biofilms
摘要
Abstract
(P < 0.05 ).Scanning electron microscopy showed that the three-dimensional structure of mix-biofilm in control group was more complex.As real-time PCR showed,after 6-hour culture,the expressions of icaA,fbe,aap,hwp1, als3 and efg1 genes in Farnesol group were down-regulated compared to those in control group and after 24-hour culture the expressions of aap,hwp1,als3 and efg1 genes in Farnesol group were down-regulated compared to those in control group.Conclusion With the intervention by fungal quorum sensing molecules Farnesol,the structure in control group became denser and more complex than that in Farnesol group.This change may have a closer correlation with the down-regulated expressions of als3,hwp1 and efg1 genes,which are related to the formation of Candida albicans biofilms.关键词
表皮葡萄球菌/白假丝酵母菌/混合生物膜/Farnesol/密度感应Key words
Staphylococcus epidermidis/Candida albicans/mixed species biofilm/Farnesol/quorum sensing分类
医药卫生引用本文复制引用
王小燕,杨堃,黄云超,郭凤丽,陈颖,雷玉洁,汤琦,刘馨..真菌密度感应分子 Farnesol 在表皮葡萄球菌和白假丝酵母菌混合生物膜形成中的作用[J].西安交通大学学报（医学版）,2015,(2):153-158,6.基金项目
国家自然科学基金(No.81260228) （No.81260228）
