西安交通大学学报（医学版）Issue(3)：404-407,413,5.DOI:10.7652/jdyxb201503024
妇炎舒胶囊对慢性子宫内膜炎大鼠的治疗作用及其机制
The therapeutic effects of Fuyanshu Capsule on chronic endometritis in rats
摘要
Abstract
Objective To observe the effects of Fuyanshu Capsule on phenol mucilage-induced endometritis rats and the possible anti-inflammation mechanism of the therapeutic effects.Methods Chronic endometritis in rats was induced by injection of phenol mucilage suspension into the uterus.Sixty female SD rats were randomly divided into 6 groups,namely,sham-operation group (distilled water,10mL/kg),model group,Jinji capsule group (0.65 g/kg),and Fuyanshu Capsule groups (1.8 g/kg,0.9 g/kg and 0.45 g/kg).After the rats were treated 28 days with corresponding medicine by intragastric administration,the pathology of the endometrium and changes of tumor necrosis factor α(TNF-α)and interleukin-2 (IL-2)levels were detected to evaluate the effects of Fuyanshu Capsule. Results Fuyanshu Capsule (1.8 g/kg and 0.9 g/kg)ameliorated the body weight reduction caused by endometritis in rats.Fuyanshu Capsule (1.8 g/kg,0.9 g/kg and 0.45 g/kg)reduced the ratio of the swelling uterus and ovaries to body weight of the rats.It ameliorated obviously the hyperplasia,necrosis and degeneration of endometrial epithelia and infiltration of inflammatory cells.The capsule (1.8 g/kg)decreased the serum IL-2 level in the rats with phenol mucilage-induced endometritis. Conclusion The anti-inflammatory effect of Fuyanshu Capsule on chronic endometritis induced by phenol mucilage in rats may be related to the decrease of IL-2 level.关键词
妇炎舒胶囊/子宫内膜炎/苯酚胶浆/炎症因子Key words
Fuyanshu Capsule/endometritis/phenol mucilage/inflammatory cytokine分类
医药卫生引用本文复制引用
黄谱,周筠,崔刚,杨宝德,赵文宝,刘传镐,胡浩..妇炎舒胶囊对慢性子宫内膜炎大鼠的治疗作用及其机制[J].西安交通大学学报（医学版）,2015,(3):404-407,413,5.基金项目
陕西省科学技术研究发展计划项目资助(No.2013K21-22-01) Supported by the Sci-tech Research and Development Project of Shaanxi Province (No.2013K21-22-01) （No.2013K21-22-01）
