西安交通大学学报（医学版）Issue(4)：449-455,490,8.DOI:10.7652/jdyxb201504005
短期高脂饮食改变大鼠对蔗糖的喜好和甜味觉的敏感性
Alterations of sucrose preference and sweet taste sensitivity after short-term high-fat diet feeding in rats
摘要
Abstract
Objective To investigate the effect of high-fat diet on the sweet taste sensitivity in rats. Methods We subjected weaning male SD rats to the new feeding environment for 1 week and then fed them with high-fat diet for 2 weeks.According to the degree of weight gain,the rats were divided into obesity-prone (OP) group,obesity-resistant (OR)group and control (C)group.OP and OR rats continued to intake high-fat diet for 8 weeks,but those in control group were fed with normal diet (C-C)for 8 weeks.By applying the conditioned taste aversion (CTA)and the double-bottle experiment,we detected sucrose detection threshold and sucrose preference, and determined the total energy intake and feed efficiency.Results ① The weight gain of OP rats fed with high-fat diet was significantly higher than that of both OR rats and control rats,while it was significantly higher in the control rats than in OR rats.② The sucrose detection threshold of rats fed with high-fat diet (OP and OR)was significantly lower than that of rats in the control group fed with normal diet,but there was no difference between OP and OR rats.③ The sucrose preference of high-fat feeding rats (OP and OR)was significantly lower than that of rats in control group fed with normal diet,but there was no difference between OP and OR rats.④ The total caloric intake of OP rats fed with high-fat diet was significantly higher than that of high-fat feeding OR rats,but there was no difference between the high-fat feeding rats and the normal diet feeding rats.⑤ Food efficiency of high-fat feeding OP rats was significantly higher than that of OR rats fed with high-fat diet and control rats fed with normal diet,but there was no difference between high-fat feeding OR rats and normal diet feeding rats.Conclusion High-fat diet influences sweet taste sensitivity,which affects the feeding behavior and then results in obesity.关键词
高脂饮食/正常饮食/甜味觉敏感性/蔗糖喜好/SD大鼠/肥胖Key words
high-fat diet/normal diet/sweet taste sensitivity/sucrose preference/Sprague-Dawley rat/obesity分类
医药卫生引用本文复制引用
孙慧玲,闫君宝,吕波,孙波,李金容,闫剑群..短期高脂饮食改变大鼠对蔗糖的喜好和甜味觉的敏感性[J].西安交通大学学报（医学版）,2015,(4):449-455,490,8.基金项目
国家自然科学基金资助项目(No.31371107),陕西省科技攻关资助项目(No.2014K11-03-08-06) Supported by the National Natural Science Foundation of China (No.31371107)and the Science and Technology Plan Project of Shaanxi Province (No.2014K11-03-08-06) （No.31371107）
