现代妇产科进展Issue(5)：351-353,3.DOI:10.13283/j.cnki.xdfckjz.2014.05.007
不同方法治疗子宫内膜单纯性增生的疗效观察
Efficacy of different therapies in treatment of simple endometrial hyperplasia
摘要
Abstract
Objective:To evaluate the efficacy and safety of hormonal therapy,oral con-traceptives( OCs) and levonorgestrel-releasing intrauterine system( LNG-IUS) on simple hyper-plasia in women. Methods:243 patients,aged 50 years or younger,who were diagnosed by path-ologic results were recruited in Qilu Hospital of Shandong University from August 2010 to June 2013. They were divided into three groups randomly and treated by progestins (group A),OCs ( group B) or LNG-IUS ( group C) for 6 months. All patients underwent pathologic examination every 3 months since the beginning of treatment. Results:Pathologic complete response rate of three groups in 6 months were 97. 5%(group A),96. 3%(group B),100%(group C),there was no statistical significance (P>0. 05). On the contrary,there was significant difference in u-terine breakthrough bleeding(16. 0%,group A;6. 1%,group B;22. 2%,group C)(P<0. 025) and weight gain (51. 9%,group A;6. 1%,group B;4. 9%,group C)(P<0. 005),but not in gastrointestinal symptom. None of these patients had adverse effects of vein thrombosis and liver dysfunctions. Conclusions:All three therapies could be the first choice for simple hyperplasia in <br> women with 50 years old or younger. Individualized treatment should be made in consideration of patients' willingness,compliance and reaction to those therapies.关键词
子宫内膜单纯性增生/治疗/孕激素/口服避孕药/LNG-IUSKey words
Simple hyperplasia/Treatment/Progestin/Oral contraceptives/Levonorg-estrel-releasing intrauterine system( LNG-IUS)分类
医药卫生引用本文复制引用
孙清,杨兴升,何淼龙,李玲,吴倩,王秀珍..不同方法治疗子宫内膜单纯性增生的疗效观察[J].现代妇产科进展,2014,(5):351-353,3.基金项目
卫生行业科研专项(No:201002013) （No:201002013）
