现代妇产科进展Issue(6)：436-439,4.DOI:10.13283/j.cnki.xdfckjz.2014.06.005
高精度持续循环腹腔热灌注化疗联合静脉化疗治疗卵巢浆液性囊腺癌的临床研究
The clinical study of continous hyperthermic peritoneal perfusion chemotherapy com-bined with intravenous chemotherapy in the treatment of ovary serous cystadenocarcino-ma
摘要
Abstract
Objective:To explore curative effect and side effects of the patients with o-vary serous cystadenocarcinoma after satisfied cytoreductive surgery administered by continous hyperthermic peritoneal perfusion chemotherapy ( CHPPC ) in combination with intravenous chemotherapy( IC) . Method:60 cases of ovarian serous cystadenocarcinoma patients after satis-fied cytoreductive surgery were divided into experimental group and the control group(n=30). Experimental group received CHPPC+IC,and control group only received IC. Results:In exper-imental group and control group, the serum CA125 half-life <20 days respectively taked up 76 . 67%,43 . 33%. And the differences were statistically significant ( P<0 . 05 ) . According to the evaluation criteria recommended by PECIST,the effective rate of the experimental group and control group were respectively 80. 00%,53. 33%(P<0. 05). For the side effects,the gastroin-testinal side effect were respectively 96 . 67%,80 . 00% in experimental group and the control group (P<0. 05). While other side effects did not have statistically significant(P>0. 05). Fol-lowed up for 6 ~15 months, recurrence rates of the experimental group and the control group were 13. 33% and 36. 67% respectively. After a follow-up of 15 months,survival rates were 90. 0%,70. 0% respectively,and the differences were statistically significant(P<0. 05). Con-clusion:CHPPC+IC is a safe,feasible treatment modality for patients with ovary serous cystade-nocarcinoma. It has an acceptable complications rate,ensures a marked improvement in survival and reduces the recurrence rate.关键词
卵巢浆液性囊腺癌/高精度持续循环腹腔热灌注联合静脉化疗/单纯静脉化疗/疗效/毒副作用Key words
Ovarian serous cystadenocarcinoma/Continous hyperthermic peritoneal perfusion chemotherapy combined with intravenous chemotherapy/Intravenous chemotherapy/Curative effect/Side effects分类
医药卫生引用本文复制引用
张艳,张菊新..高精度持续循环腹腔热灌注化疗联合静脉化疗治疗卵巢浆液性囊腺癌的临床研究[J].现代妇产科进展,2014,(6):436-439,4.基金项目
河南省普通科技攻关项目(No:132102310062) （No:132102310062）
