现代妇产科进展Issue(7)：517-519,3.DOI:10.13283/j.cnki.xdfckjz.2014.07.003
妊娠滋养细胞疾病中EMT相关蛋白CK19和N-cad表达的研究
The expression of epithelial to mesenchymal transition associated protein of CK19 and N-cad in gestational trophoblastic disease
摘要
Abstract
Objective:To explore the role of epithelial to mesenchymal transition (EMT) associated protein of Cytokeratin 19 (CK19) and N-cadherin (N-cad) in oncogenesis, development of gestational trophoblastic disease ( GTD) . Methods:CK19 and N-cad were de-tected Immunohistochemically in paraffin-embedded tissue of 41 cases of normal placenta ( NP) ,31 cases of hydatidiform mole ( HM ) , 32 cases of gestational trophoblastic neoplasia ( GTN ) [ 26 cases of invasive hydatidiform mole ( IM ) and 6 cases of choriocarcinoma (CCA)]. Results:In NP,HM and GTN,the median mean density of CK19 was (7. 62±5. 54) ×10-2,(4. 76±3. 33)×10-2,(3. 20±3. 84)×10-2,respectively,the median mean density of N-cad was (10.6±8.39)×10-2,(4.15±4.19)×10-2,(2.28±3.05)×10-2,respectively. There were significant differences between NP and HM,GTN (P<0. 05),and between HM and GTN ( P<0 . 05 ) . There was no correlation between CK19 and N-cad ( r=0 . 202 , P=0 . 268 ) . Con-clusions:The expressions of CK19 and N-cad decrease with the increase of tropohblast malig-nancy which indicate that CK19 and N-cad may involve in the events of malignant transforma-tion of trophocytes,and EMT may play an important role in the malignant progression of GTD.关键词
妊娠滋养细胞疾病/上皮细胞向间质转化/细胞角蛋白19/神经钙黏蛋白/免疫组织化学Key words
Gestational trophoblastic disease/Epithelial to mesenchymal transition/Cytokeratin 19/N-cadherin/Immunohistochemistry分类
医药卫生引用本文复制引用
徐洁,薛艳,曾宪玲,安瑞芳..妊娠滋养细胞疾病中EMT相关蛋白CK19和N-cad表达的研究[J].现代妇产科进展,2014,(7):517-519,3.基金项目
国家自然科学基金(No:81172489) （No:81172489）
