现代妇产科进展Issue(7)：520-523,4.DOI:10.13283/j.cnki.xdfckjz.2014.07.004
TLRs多态性与宫颈癌易感性之间的关系
Study on TLRs polymorphisms and cervical cancer susceptibility
摘要
Abstract
Objective:To study the polymorphisms of toll-like receptor ( TLR) 2 -196 to -174 del,TLR3c. 1377C/T,TLR4 Asp299Gly,Thr399Ile and TLR9 1486T/C,G2848A and susceptibility to cervical cancer in the Han population of China. Methods:A case-control study was performed which included 102 patients with cervical cancer and 100 healthy women who acted as the control group. Polymorphism at TLR2 -196 to -174 de1 was investigated by using the allele-specific polymerase chain reaction (PCR) method,while TLR3,4,9 genes were ana-lyzed by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) . And the representative PCR products was sequenced to identify PCR-RFLP results. Results:TLR4 Asp299Gly and TLR4 Thr399Ile polymorphisms gene were not found in both groups. The single nucleotide polymorphisms of TLR2 ,3 ,9 have no significant differences between cervical cancer group and control group. Conclusion:TLR2 (-196 to -174 del),TLR3c. 1377C/T, TLR4 Asp299Gly,Thr399Ile,TLR9 1486T/C,G2848A gene polymorphisms may not be associ-ated with cervical cancer.关键词
TLR/多态性/宫颈癌Key words
Toll-like receptor/Polymorphism/Cervical cancer分类
医药卫生引用本文复制引用
毕晓宁,徐小惠,于啸,王宁,殷复粉,王言奎..TLRs多态性与宫颈癌易感性之间的关系[J].现代妇产科进展,2014,(7):520-523,4.基金项目
国家自然科学基金资助项目(No:81172480) （No:81172480）
