现代妇产科进展Issue(10)：810-812,3.DOI:10.13283/j.cnki.xdfckjz.2014.10.013
115例胎儿心脏畸形的产前诊断分析
Analysis on the prenatal diagnosis of fetal heart malformation in 115 cases
钟世林 1邓玉清 1石宇 1张蒂荣 1雷桔红1
作者信息
摘要
Abstract
Objective:To evaluate the features of fetal heart malformation and the relation-ship with chromosomal abnormality. Methods:Invasive prenatal diagnosis and chromosome analysis were given to 115 cases of fetal heart malformation diagnosed by prenatal ultrasound examination, and the type and ratio of the cardiac malformation,extracardiac malformation and chromosomal ab-normality were analyzed. Results:115 cases included 74 of single heart defect,41 of multiple heart defects,54 of simple heart defect,61 of cases with extracardiac defects. 31 of cases were complicated with chromosome abnormalities,including 15 of trisomy 21 and 11 of trisomy 18. 63. 6% of double outlet right ventricle,44. 4% of ventricular septal defects,35. 7% of complete endocardial cushion defects and 33. 3% of tricuspid regurgitation were complicated with chromosomal abnormalities re-spectively. The ratio of chromosome abnormality in single heart defect (24. 3%) was not significant-ly different from that in multiple heart defects (31. 7%)(P>0. 05). The ratio of chromosome abnor-mality in simple heart defect (14. 8%) was significantly different from that in cases with extracardi-ac defects (37. 7%)(P<0. 05). Conclusion:Extracardiac and chromosomal abnormalities are com-mon in fetal heart malformation,and aneuploid accounts for the major proportion of chromosomal ab-normalities. Double outlet right ventricle,ventricular septal defect,complete endocardial cushion de-fects and tricuspid regurgitation are frequently complicated with chromosome abnormalities. The ratio of chromosome abnormality increases in fetal heart malformation when complicated with extracardiac defects.关键词
胎儿心脏畸形/产前诊断/染色体异常Key words
Fetal heart malformation/Prenatal diagnosis/Chromosome abnormality分类
医药卫生引用本文复制引用
钟世林,邓玉清,石宇,张蒂荣,雷桔红..115例胎儿心脏畸形的产前诊断分析[J].现代妇产科进展,2014,(10):810-812,3.
