现代妇产科进展Issue(11)：877-881,5.DOI:10.13283/j.cnki.xdfckjz.2014.11.013
C 型凝集素受体和 Toll 样受体在原因不明复发性流产患者蜕膜中的表达
Expression of C-type lectin receptors and Toll-like receptors in decidua of unexplained recurrent spontaneous abortion. Expression of C-type lectin receptors and Toll-like receptors in decidua of unexplained recurrent spontaneous abortion
摘要
Abstract
Objective:To investigate the expression of C-typed lectin receptors (CLRs) of DC-SIGN and MR and Toll-like receptors (TLRs) of TLR-2 and TLR-4 in decidua of unex-plained recurrent spontaneous abortion( URSA) patients. Methods:The decidua tissues were obtained from URSA patients (URSA group,n =20) and normal pregnant women (NP group,n= 20). The expressions of DCSIGN,MR,TLR-2 and TLR-4 protein in decidua were detected by immunohistochemistry and Western blot. The levels of DCSIGN,MR,TLR-2 and TLR-4 mRNA in decidua were detected by RT-PCR. The expressions of DCSIGN,MR,TLR-2 and TLR-4 mol-ecule on DC were detected by flow cytometry. Results:The expressions of TLR-2 and TLR-4 on DC and in decidua in URSA group were higher than that in NP group (P<0. 05 and P<0. 01 respectively). The expression of DC-SIGN in URSA group was significantly lower than that in NP group (P<0. 01). There was no significant difference in the expression of MR between two groups (P>0. 05). Conclusion:Compared with normal pregnant women,the weak expression of CLRs and the overexpression of TLRs were observed in decidua in URSA patients. The imbal-ance between CLRs and TLRs may play an important role in the pathogenesis of URSA.关键词
原因不明复发性流产/蜕膜/C 型凝集素受体/Toll 样受体Key words
unexplained recurrent spontaneous abortion/decidua/C-type lectin recep-tors/Toll-like receptors分类
医药卫生引用本文复制引用
邱添,滕银成,王玉东,徐亮..C 型凝集素受体和 Toll 样受体在原因不明复发性流产患者蜕膜中的表达[J].现代妇产科进展,2014,(11):877-881,5.基金项目
国家自然科学基金青年项目(No:81100474) （No:81100474）
