现代妇产科进展Issue(12)：942-945,4.DOI:10.13283/j.cnki.xdfckjz.2014.12.005
mTOR信号通路在人子宫肌和子宫肌瘤组织中的活性研究
The activity of mTOR signal pathway in human myometrium and uterine leiomyoma
摘要
Abstract
Objective:To investigate the activation of mTOR ( mammalian target of ra-pamycin) signal pathway related proteins in human myometrium and their matched uterine leio-myomas. Methods:The expression levels of tuberin,hamartin,p-S6K,p-4EBP1 and p-Akt were detected in human uterine leiomyoma and their matched myometrial tissues from 22 Chinese pa-tients by Western blot and Real-time polymerase chain reaction ( RT-qPCR) analyses. Results:The expression of tuberin, but not hamartin, was significantly increased in leiomyoma tissues compared with the matched normal myometrium. The phosphorylation levels of both S6K and 4EBP1 were down-regulated in human leiomyoma. However, the mRNA levels of S6K and 4EBP1 were up-regulated in human leiomyoma. There were no statistical differences between the expression levels of Akt and p-Akt in both tissues. Conclusion:The expression of tuberin was significantly increased in leiomyoma tissues with the inhibition of the mTOR signaling path-way.关键词
子宫肌瘤/Tuberin/哺乳动物雷帕霉素靶分子( mTOR)Key words
Uterine leiomyoma/Tuberin/Mammalian target of rapamycin( mTOR)分类
医药卫生引用本文复制引用
周玉,许丽娟,王天齐,马迪,李阳,李宗金,王悦冰..mTOR信号通路在人子宫肌和子宫肌瘤组织中的活性研究[J].现代妇产科进展,2014,(12):942-945,4.基金项目
南开大学本科生创新科研计划项目(No:ZB140047) （No:ZB140047）
南开大学基础科研业务费(No:65011281) （No:65011281）
