现代妇产科进展Issue(6)：408-411,4.DOI:10.13283/j.cnki.xdfckjz.2015.06.003
神经细胞黏附因子在子宫腺肌病病灶中的表达及意义
Expression and significance of neural cell adhesion molecule in adenomyosis
摘要
Abstract
Objective:To investigate the expression of neural cell adhesion molecule ( NCAM) in the eutopic endometrium and ectopic lesions from patients in adenomyosis and its possible role in the pethogenesis of adenomyosis. Methods:The expressions of NCAM in the eu-topic and ectopic samples of adenomyosis were assayed by immunohistochemical staining and the result was compared with the normal endometrial samples by H-score method. Result:NCAM was observed in the endometrial glandular epithelium of all the ectopic and ectopic sam-ples and 19 normal samples. No positive results were observed in stroma. The staining intensity of NCAM in ectopic lesion was significantly higher than that in the eutopic endometrium and normal endometrium ( P<0 . 01 ) , whereas no statistical difference was observed in the expres-sion between the eutopic endometrium and normal endometrium of patients with adenomyosis. For eutopic endometrium of adenomyosis,expression was higher in the secretory phase than that in the proliferative phase(P<0. 05). The expression of NCAM in ectopic lesion of adenomyosis was positively correlated with the severity of dysmenorrhea ( r=0 . 84 , P<0 . 01 ) . Conclusions:NCAM may participate in the occurrence and development of adenomyosis and may contributes to the occurrence and development of dymenorrhea,but the exact moleculor mechanisms still re-main to be discovered.关键词
NCAM/子宫腺肌病/子宫内膜/免疫组化Key words
NCAM/Adenomyosis/Endometrium/Immunohistochemistry分类
医药卫生引用本文复制引用
石茜茜,李辉,秦晓燕,王芳,温泽清,李长忠,王飞..神经细胞黏附因子在子宫腺肌病病灶中的表达及意义[J].现代妇产科进展,2015,(6):408-411,4.基金项目
国家自然科学基金资助项目(No:81200426)；山东省自然科学基金资助项目(No. ZR2013HM060；No:ZR2011HQ046)；山东省科技发展计划(No:2014GSF118048) （No:81200426）
