摘要
Abstract
Objective:To explore the effective factors for sensitivity of neoadjuvant chemotherapy( NACT) in cervical cancer. Methods:Stage IB2 to IIB disease was present in 106 patients which were all undertaken 1~3 courses of NACT and radical hysterectomy in our hos-pital during Apr. 2011 and Feb. 2015. Efficacy was evaluated preoperatively. To analyze the re-lationship of NACT sensitivity with pathological type,clinical stage,tumor diameter,grade of dif-ferentiation,pretreatment level of serum squamous cell carcinoma antigen ( SCC-Ag) ,hemoglo-bin,platelets,platelet and lymphocyte ratio (PLR). Results:The efficiency was 64. 15%(68/106 ) . Time of operation and the rate of lymph node metastasis and cervical deep stromal infil-tration in effective group was significantly lower than that in invalid group(P<0. 05). Univariate analysis showed that pretreatment tumor diameter, SCC-Ag, PLR was significantly related to NACT sensitivity(P<0. 05). Multivariate analysis showed those pretreatment tumor diameter, SCC-Ag,PLR were independently correlated with NACT sensitivity in cervical cancer ( P<0. 05). Conclusions:Pretreatment tumor diameter,SCC-Ag and PLR showed potentially predic-tive value of NACT sensitivity in cervical cancer.关键词
宫颈癌/新辅助化疗/敏感性/血小板与淋巴细胞比值Key words
Cervical cancer/Neoadjuvant chemotherapy(NACT)/Sensitivity/Platelet and lymphocyte ratio( PLR)分类
医药卫生
