中国组织工程研究Issue(15)：2326-2331,6.DOI:10.3969/j.issn.2095-4344.2014.15.006
低浓度尼古丁对大鼠硬腭软组织缺损愈合的影响
Effect of low concentration of nicotine on soft tissue defect repair of rat hard palate
摘要
Abstract
BACKGROUND:Low concentration of nicotine promotes the angiogenesis and facilitates the healing of skin wounds. However, the role of low concentration of nicotine on the repair of maxil ofacial soft tissue trauma especial y oral mucosa stil remains unclear <br> OBJECTIVE:To evaluate the effect of low concentration of nicotine on mucosa defect repair of rat hard palate. <br> METHODS:A circular soft tissue defect at 3 mm diameter was produced in the centre of hard palate of 65 Wistar rats. After the operation, animals were randomly divided into low concentration of nicotine with gel group, gel group and control group. Rats were sacrificed at 3, 7, 10 and 14 days post-surgery. The wound healing was detected with hematoxylin-eosin staining and the difference of wound healing in different groups was compared with gross observation and image measurement. <br> RESULTS AND CONCLUSION:There was no significant difference in the wound healing in different groups on day 3 post-surgery. On days 7 and 10, the group of low concentrations of nicotine with gel was faster than gel group and control group (P<0.05);the wounds were completely healed on day 14, with no significant difference among the groups. Low concentrations of nicotine may promote the mucosa defects repair of rat hard palate.关键词
组织构建/软组织构建/尼古丁/软组织缺损/凝胶/创面愈合率/硬腭/国家自然科学基金Key words
nicotine/cleft palate/palate, hard/soft tissue injuries/mouth mucosa分类
医药卫生引用本文复制引用
张亚军,杨聪翀,刘来奎,张梦洁,孙应明..低浓度尼古丁对大鼠硬腭软组织缺损愈合的影响[J].中国组织工程研究,2014,(15):2326-2331,6.基金项目
国家自然科学基金(81272968)@@@@the National Natural Science Foundation of China, No.81272968 （81272968）
