中国组织工程研究Issue(15)：2403-2408,6.DOI:10.3969/j.issn.2095-4344.2014.15.018
快速成型钛板结合自体骨移植修复犬下颌骨缺损
Rapid prototyped titanium plate combined with autologous cancellous bone graft repairs canine mandibular defects
周丽斌 1刘彦普 2吴玮 1王佩林 1丁瑞英 1韩浩伦 1李保卫 1王刚 1王鸿南 1赵晋龙2
作者信息
- 1. 解放军第306医院耳鼻咽喉头颈外科，北京市 100101
- 2. 解放军第四军医大学口腔医院口腔颌面外科，陕西省西安市 710032
- 折叠
摘要
Abstract
BACKGROUND:Rapid prototyping technique has been recently applied in the medical reconstruction and al ows the production of individual implant for patients with tissue defects, achieving an accurate repair. <br> OBJECTIVE:To repair discontinuous mandibular defects in dogs using rapid prototyped titanium plate in combination with autologous cancellous bone graft. <br> METHODS:Nine hybrid canines were used, and the skul was scanned using spiral CT. Then CT data were used to construct three-dimensional digital model, in which virtual partial mandibulectomy was performed, and an individualized bone-grafting plate was designed. A titanium plate was manufactured using rapid prototyping and titanium casting. Animal experiment was then performed. A 40-mm discontinuous defect in the right mandibular body was created in the involved dogs. The defect was restored immediately using the customized plate in combination with autologous cancellous iliac blocks. Sequential radionuclide bone imaging, biomechanical testing, three-dimensional microcomputed tomographic scanning, radiology and histological examination were used to evaluate the turnover of the grafts. <br> RESULTS AND CONCLUSION:A symmetric mandible was reconstructed using the rapid prototyped grafting plate. The grafted bone survived and got corticalized, while a fibrous intermedium was found between the bone graft and the plate. In the reconstruction of mandibular defects, optimal functional and aesthetic outcomes could be achieved using the rapid prototyped grafting plates.关键词
组织构建/骨组织工程/下颌骨缺损/钛板/髂骨移植/计算机辅助设计/快速成型/核素骨显像/修复体Key words
mandible/titanium/braces/ilium/bone transplantation/tomography, spiral computed分类
医药卫生引用本文复制引用
周丽斌,刘彦普,吴玮,王佩林,丁瑞英,韩浩伦,李保卫,王刚,王鸿南,赵晋龙..快速成型钛板结合自体骨移植修复犬下颌骨缺损[J].中国组织工程研究,2014,(15):2403-2408,6.
