中国组织工程研究Issue(15)：2442-2449,8.DOI:10.3969/j.issn.2095-4344.2014.15.024
甲状旁腺激素相关肽与糖尿病性骨质疏松性骨折：你知道哪些？
Parathyroid hormone related peptides affect diabetic osteoporotic fracture
摘要
Abstract
BACKGROUND:Parathyroid hormone related peptides are accompanied by the syndrome of humoral hypercalcemia of malignancy. As a potential therapeutic drug of promoting the healing of bone fracture, parathyroid hormone related peptides have significant clinical application value. <br> OBJECTIVE:To explore the regulating effects of parathyroid hormone related peptides in diabetic osteoporotic fracture <br> METHODS:A computer-based online research of CNKI and PubMed databases was performed to col ect articles published between 1990 and 2013, with the key words“parathyroid hormone related peptides, diabetes, osteoporotic fracture”in Chinese and English. There were 1 279 articles after the initial survey. A total of 43 articles were included according inclusion and exclusion criteria. <br> RESULTS AND CONCLUSION:Animal and clinical experiments demonstrated that parathyroid hormone related peptides notably accelerate bone fracture healing, and improve the repair process of islet cellfunction defects that are related with diabetes. Meanwhile, as an analogue, parathyroid hormone has been identified as clinical medication in the treatment of fracture. But the appropriate dose, and method of application at the different stages of bone fracture healing and the problem of drug combination need further investigation.关键词
组织构建/骨组织工程/甲状旁腺激素相关肽/糖尿病/骨质疏松/骨折/国家自然科学基金Key words
parathyroid hormone/diabetes mel itus/osteoporosis/osteoporotic fractures分类
医药卫生引用本文复制引用
刘岸龙,邱勇,王银河..甲状旁腺激素相关肽与糖尿病性骨质疏松性骨折：你知道哪些？[J].中国组织工程研究,2014,(15):2442-2449,8.基金项目
国家自然科学基金(81271997)；南京市卫生局重点课题(ZKX10007)；中国博士后基金(20100481130)；江苏省“科教兴卫”医学重点人才(RC2011150)@@@@the National Natural Science Foundation of China, No.81271997 （81271997）
Key Project of Nanjing Municipal Health Bureau, No. ZKX10007 （）
China Postdoctoral Science Foundation, No.20100481130 （）
Key Program for Medical Talents of Jiangsu Province, No. RC2011150 （）
