中国组织工程研究Issue(16)：2474-2479,6.DOI:10.3969/j.issn.2095-4344.2014.16.003
磷酸三钙多孔生物陶瓷修复股骨头坏死
Porous bioceramic beta-tricalcium phosphate for treatment of osteonecrosis of the femoral head
摘要
Abstract
BACKGROUND:It is a clinical difficult in the treatment of osteonecrosis with joint preservation, and to solve this problem, a variety of bone graft substitutes are at the exploration stage. OBJECTIVE:To evaluate the clinical outcome of lightbulb operation with porous bioceramic β-tricalcium phosphate in a consecutive series of patients with osteonecrosis of the femoral head. METHODS:From January to December 2008, 58 patients (88 hips) who had undergone lightbulb operation with porous bioceramic β-tricalcium phosphate were involved in this study. Al patients were evaluated both clinicaly and radiographicaly at postoperative 3, 6, 12 months and annualy. Functional improvement was assessed with the Harris hip score. RESULTS AND CONCLUSION: Among these patients, 56 patients (85 hips) were folowed up for 2-5 years. According to the ARCO staging system, there were 27 hips of stage II, 40 hips of stage IIIa, 18 hips of IIIb. According to the hospital’s classification, type C was in 4 hips, L1 in 15 hips, L2 in 28 hips, and L3 in 38 hips. According to the Harris hip score system, excelent outcome was in 55 hips, good in 12 hips, fair in 5 hips and poor in 13 hips. Nine of 11 patients who failed to preserve their own joints were subjected to hip replacement. The  mean preoperative and postoperative Harris scores were 61.2 and 85.3, respectively, with a mean improvement of 24.1 points (P < 0.001). All hips were radiologically stable, with no progress of osteonecrosis, and bone density in the bone graft area increased obviously. The replacement time of porous bioceramic β-tricalcium phosphate was 1-1.5 years. These findings suggest that the porous bioceramic β-tricalcium phosphate provides an option to treat osteonecrosis of the femoral head with satisfactory clinical outcomes, and profits the repair and reconstruction of femoral head osteonecrosis. When in the lateral column of femoral head, the porous bioceramic β-tricalcium phosphate can play a supporting role in the lateral column of the necrotic area, and further prevent collapse, which is suitable for patients with osteonecrosis of the femoral head, especially for those with joint preservation.关键词
生物材料/骨生物材料/股骨头坏死/磷酸三钙多孔生物陶瓷/关节功能/生物相容性/国家自然科学基金Key words
femur head necrosis/bone transplantation/bone substitutes/treatment outcome分类
医药卫生引用本文复制引用
孙伟,李子荣,高福强,史振才,王佰亮,郭万首..磷酸三钙多孔生物陶瓷修复股骨头坏死[J].中国组织工程研究,2014,(16):2474-2479,6.基金项目
国家自然科学基金面上项目(81372013)；卫生部部属(管)临床重点学科项目(2009-2012)；中日友好医院院级课题(2013-MS-27)；中日友好医院科技英才计划(2004-QNYC-A-06) （81372013）
