中国组织工程研究Issue(16)：2532-2537,6.DOI:10.3969/j.issn.2095-4344.2014.16.012
墨鱼骨转化羟基磷灰石制备及细胞相容性
Preparation and cytocompatibility of cuttlebone-transformed hydroxyapatite
摘要
Abstract
BACKGROUND:Recently, bone tissue engineering is highlighted from the nature source. OBJECTIVE:To explore the preparation of a cuttlebone-transformed hydroxyapatite scaffold as the novel bone substitution. METHODS: As raw materials, the cuttlebone appeared to have a hydrothermal reaction with diammonium phosphate under specific conditions, and the hydrothermal products were characterized respectively by X-ray diffraction, Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy and scanning electron microscopy. RESULTS AND CONCLUSION:The results showed that the hydrothermal products were hydroxyapatite. The cuttlebone-transformed hydroxyapatite possessed good three-dimensional structure. Cytocompatibility of the cuttlebone-transformed hydroxyapatite with MG63 cels culturedin vitro were observed and we found the cuttlebone-transformed hydroxyapatite had no obvious effects on cellgrowth and no toxicity, which can be used as new bone tissue engineering scaffolds.关键词
生物材料/骨生物材料/材料相容性/墨鱼骨/磷酸二铵/水热反应/羟基磷灰石/细胞相容性/海南省自然科学基金Key words
hydroxyapatites/durapatite/biocompatible materials/stents分类
医药卫生引用本文复制引用
黄谢山,刘明,王江..墨鱼骨转化羟基磷灰石制备及细胞相容性[J].中国组织工程研究,2014,(16):2532-2537,6.基金项目
海南省重点科技计划(ZDXM20120066)；海南省自然科学基金(511106) （ZDXM20120066）
