中国组织工程研究Issue(16)：2576-2581,6.DOI:10.3969/j.issn.2095-4344.2014.16.019
丝素蛋白在小口径人工血管中的应用
Fibroin in small-caliber vascular prostheses
摘要
Abstract
BACKGROUND:Many scholars have successfuly applied silk fibroin into smal-caliber vascular prostheses to achieve better anti-thrombotic role and excelent mechanical strength. In the animal experiments, an ideal long-term patency has been achieved. OBJECTIVE:To summarize the biochemical properties of silk fibroin, the currently used methods for the vessel modification, as wel as specific applications of silk fibroin in smal-caliber vascular prostheses. Methods: A computer-based search of CNKI, Medline database and ScienceDirect databases from January 1980 to December 2013 was performed for articles relevant to smal-caliber vascular prostheses with the key words of “vascular grafts, silk fibroin” in Chinese and English. RESULTS AND CONCLUSION:Silk fibroin has controlable mechanical properties and good biocompatibility. Its decomposition products is wel known and non-toxic. In addition, silk fibroin is easy to be integrated by anticoagulant group, and the effect is obvious, reliable, and easy for colonization and growth of endothelial cels, which can bring a satisfactory long-term patency. So, silk fibroin is an ideal material for the smal-caliber vascular prostheses. However, due to the production process and other issues, the application of silk fibroin in previous studies has no long-term development. Recently, the development of nano-materials, bionic technology, vascular tissue engineering, and electrospinning technology brings new chances for the application of silk fibroin in artificial vessels.关键词
生物材料/材料相容性/丝素蛋白/人工血管/小口径/组织工程/综述Key words
biocompatible materials/silk/blood vessel prosthesis/tissue engineering/review分类
医药卫生引用本文复制引用
孙浩,闫玉生,陈群清,李少彬..丝素蛋白在小口径人工血管中的应用[J].中国组织工程研究,2014,(16):2576-2581,6.基金项目
2009年广东省科技计划项目(93025) （93025）
