中国组织工程研究Issue(20)：3212-3217,6.DOI:10.3969/j.issn.2095-4344.2014.20.018
犬牙槽骨牵张成骨的生物力学和组织学分析
Biomechanical and histological analysis of alveolar distraction osteogenesis in a canine model
摘要
Abstract
BACKGROUND:Alveolar distraction osteogenesis is an important method for treating alveolar bone atrophy, the osteogenesis process and biomechanics play a crucial role in the fol owing implantation and repair. At present, no related experimental studies are found. <br> OBJECTIVE:To analyze the biomechanical and histological characteristics of alveolar distraction osteogenesis in a canine model. <br> METHODS:Twelve adult mongrel canines received premolars extraction and alveoloplasty in mandible to establish an atrophy alveolar model. After 3 months, a segmental alveolar osteotomy was performed in the randomly selected unilateral atrophy alveolar and two intra-osseous distractors were placed. After a 7-days latency period, the alveolar ridge was augmented at a rate of 1.0 mm/d for 5 days. After a consolidation of 1, 2, and 3 months, the canines were sacrificed and the specimens of the distracted alveolar bone were harvested for clinical, radiographic, histological and biomechanical analysis. <br> RESULTS AND CONCLUSION:The alveolar distractors obtained good healing with surrounding tissue. The atrophy alveolar bones were augmented for (4.80±0.50) mm and (5.12±0.47) mm by clinical and radiographic findings immediately after distraction, respectively. The bone trabeculae in the distracted chamber matured from 1 to 3 months of consolidation by histological analysis. The shearing force of alveolar distraction chamber increased from 1 to 3 months. After 3 months’ consolidation, the shearing force of distracted chamber was comparable to host bone. The histological and biomechanical property of distracted alveolar chamber is comparable to host bone after 3 months’ consolidation.关键词
组织构建/骨组织工程/牙槽骨牵张成骨/力学/组织学/牙种植/犬/国家自然科学基金Key words
osteogenesis, distraction/mechanics/histology/dental implantation分类
医药卫生引用本文复制引用
周苗,车月娟,郭明炎,黄代营,朴正国,庾晓伟,陈松龄..犬牙槽骨牵张成骨的生物力学和组织学分析[J].中国组织工程研究,2014,(20):3212-3217,6.基金项目
国家自然科学基金(81000421)；广东省科技计划重点资助项目(2004B33101010)；ITI基金(881-2012) （81000421）
