中国组织工程研究Issue(21)：3367-3373,7.DOI:10.3969/j.issn.2095-4344.2014.21.016
胶原/生物活性玻璃/壳聚糖增强型复合支架
Collagen/bioactive glass/chitosan composite scaffolds
摘要
Abstract
BACKGROUND:Col agen/bioactive glass composite materials possess excellent osteogenic potential and biocompatibility, but its application in bone tissue engineering is limited by mechanical property and degradation. OBJECTIVE:To construct col agen/bioactive glass/chitosan composite scaffolds with good mechanical property, anti-degradation ability and bone repair property. <br> METHODS:Bioactive glass/col agen composite scaffolds with chitosan as dispersant were prepared by lyophylization. Fourier transform infrared spectroscopy, scanning electron microscope, X-ray diffraction, and dynamic biomechanical testing were used to characterize the structure and properties of the composite scaffolds. RESULTS AND CONCLUSION:Results show that charge-attractions in pre-prepared bioactive glass/chitosan solution increased the homogeneity of bioactive glass dispersed in col agen gel and the compressive modulus and strength increased significantly due to the homogeneity and intermolecular interactions between chitosan and col agen. The enzymatic degradation rate and mineralization activity in the simulated body fluid were also lower because of a high degree of embedment of bioactive glass in col agen/chitosan matrix, and entanglement of col agen in chitosan at molecular level, which decreased the exposure of bioactive glass to the simulated body fluid, and col agen to enzyme solution.关键词
生物材料/骨生物材料/壳聚糖/分散/生物活性玻璃/胶原/支架/国家自然科学基金Key words
biocompatible materials/chitosan/col agen/glass分类
医药卫生引用本文复制引用
孟永春,陈晓峰,南开辉,李玉莉,罗小刚,邓春林..胶原/生物活性玻璃/壳聚糖增强型复合支架[J].中国组织工程研究,2014,(21):3367-3373,7.基金项目
浙江省自然科学基金(Y407241)；国家自然科学基金(51072055)；国家自然科学基金重点项目(50830101)；国家重点基础研究发展计划(973计划)(2011CB606204)资助 （Y407241）
