摘要
Abstract
BACKGROUND:Cardiovascular biomaterials applied under the blood-contact conditions must have anti-thrombotic, anti-biodegradable and anti-infective properties. OBJECTIVE:To develop novel polymer materials for implantation and intervention in cardiovascular tissue engineering and then to explore the biological, blood and cellcompatibilities of corresponding surface-modified polymer biomaterials based on surface construction and biological response. <br> METHODS:We retrieved PubMed and WanFang databases for relevant articles publishing from 1984 to 2013. The key words were“biocompatibility, blood compatibility, biomedical materials, biomedical polymer materials”in English and Chinese, respectively. <br> RESULTS AND CONCLUSION:Here, we analyze the fol owing four aspects:protein adsorption, biometric identification in celladhesion, and the“waterfal model”for enzyme catalysis during blood coagulation and fibrinolysis. Consequently, it is concluded that the functional surface construction of polymer biomaterials and research on corresponding biocompatibility and endothelial cellcompatibility are crucial for developing novel polymer materials for implantation and intervention in cardiovascular tissue engineering. Through in-depth studies of the types and applications of polymer biomaterials, cardiovascular medical devices and implantable soft tissue substitutes, the differences between the surface and the body wil be reflected in the many layers of molecules extending from the surface to the body. Two major factors, surface energy and molecular mobility, determine the body/surface behaviors that include body/surface differences and phase separation. Considering the difference between body/surface composition, an additional determinant is indispensable, that is the crystal ization behavior of each component.关键词
生物材料/材料相容性/血液相容性/细胞相容性/聚合物/医用高分子材料/生物识别/生物材料的表面构建/蛋白质的表面吸附Key words
biocompatible materials/polymers/biometric identification/tissue engineering分类
医药卫生
