中国组织工程研究Issue(23)：3762-3767,6.DOI:10.3969/j.issn.2095-4344.2014.23.026
甲状腺肿瘤干细胞与甲状腺肿瘤治疗：理论与应用
Thyroid cancer stem cells and thyroid cancer treatment:theory and applications
摘要
Abstract
BACKGROUND:Thyroid cancer stem cells are one of the reasons for tumor resistance that promotes tumor development. The research of thyroid cancer stem cells has provides a new clinic means for the diagnosis and treatment of thyroid cancer. OBJECTIVE:To overview the discovery, identification, and correlation of thyroid cancer stem cells with thyroid cancer. METHODS:A computer-based online search of PubMed database and Wan Fang database between 1995-01/2014-01 was performed to search related articles with the key words of“thyroid cancer, cancer stem cell, stem cell, cancer suppressor gene”in English and Chinese, respectively. Literatures related to thyroid cancer stem cells were selected;in the same field, the articles published lately in authoritative journals were preferred. RESULTS AND CONCLUSION:A total of 561 literatures were primarily selected, and 57 documents were involved for result analysis according to inclusion criteria. Cancer stem cells have become a focus in the study of carcinogenesis. Stem cells also exist in the thyroid gland and its tumor. At present, there are several ways to isolate and identify thyroid cancer stem cells. The tumor thyroid stem cells are closely related to the occurrence, transfer and treatment of tumors. But whether we can cure thyroid cancer through restraining or eliminating thyroid cancer stem cells is stil unknown that needs further studies.关键词
干细胞/肿瘤干细胞/甲状腺肿瘤/肿瘤抑癌基因/内蒙古自治区自然科学基金Key words
stem cells/thyroid neoplasms/neoplastic stem cells/review分类
医药卫生引用本文复制引用
赛恒,毕力夫,吴岩..甲状腺肿瘤干细胞与甲状腺肿瘤治疗：理论与应用[J].中国组织工程研究,2014,(23):3762-3767,6.基金项目
内蒙古自治区自然科学基金(5012012-00N0-N00041CZT)Funding:the Natural Science Foundation of Inner Mongolia Autonomous Region, No.5012012-00N0-N00041CZT （5012012-00N0-N00041CZT）
