中国组织工程研究Issue(30)：4868-4872,5.DOI:10.3969/j.issn.2095-4344.2014.30.018
超声波对高分子材料降解过程启动的控制
Ultrasonic controlling of degradation of polymer materials
摘要
Abstract
BACKGROUND:Degradable polymer materials initiate the degradation process immediately after implantation. How to regulate the degradation of these materials is rarely reported at present. OBJECTIVE:To study the effect of ultrasonic wave on control ing the degradation of polymer materials. METHODS:The sample is made ofε-caprolactone/L-lactide copolymer, and its core was coated with low density polyethylene on the surface with the fol owing four different methods. (1) The core surface was firstly covered with CaCl 2 powder, and then coated with polyethylene. (2) The core was firstly coated with polyethylene and coarsened for 3 hours. (3) The core surface was firstly covered with CaCl 2 powder, and then coated with polyethylene, and coarsened for 3 hours. (4) The core was directly coated with polyethylene. The four kinds of specimens obtained were embedded in pork for ultrasonic bombardment experiment in vitro. RESULTS AND CONCLUSION:In the specimens prepared with methods 1 and 4, the lyophobic layer could protect core materials before ultrasonic treatment, and no absorption peak was found at 631 nm. After ultrasonic treatment, the lyophobic layer was destroyed, toluidine blue dye was released, leading to change the color of immersion solution and increase the absorption peak at 631 nm. In the specimens prepared with methods 2 and 3,the lyophobic layer cannot exhibit the protection effects, the absorption peak was found at 631 nm. Under electron microscope, the appearance of the specimens in four groups was changed obviously. It is feasible to control the starting of the degradation by coating the degradable copolymer with LDPE and using ultrasonic as a trigger.关键词
生物材料/共聚物/ε-己内酯/L-丙交酯/生物可降解材料/低密度聚乙烯/组织工程人工血管/药物控释/国家自然科学基金Key words
polyethylene/biodegradation, environmental/polymers分类
医药卫生引用本文复制引用
高喜翔,张建,陈兵,谷涌泉,李建新,张淑文,叶霖,冯增国..超声波对高分子材料降解过程启动的控制[J].中国组织工程研究,2014,(30):4868-4872,5.基金项目
国家自然科学基金资助项目(30972944)；北京市科学技术委员会"首都临床特色应用研究"专项资助课题(Z131107002213041)@@@@the National Natural Science Foundation of China, No.30972944 （30972944）
Capital Medicine Clinical Application Project by Beijing Municipal Science andTechnology Commission, No. Z131107002213041 （）
