芒果苷对缺氧损伤骨髓间充质干细胞的保护作用OA北大核心CSTPCD
Mangiferin protects bone marrow mesenchymal stem cells against hypoxia
背景：研究表明骨髓间充质干细胞移植在临床治疗方面具有广阔的应用前景。然而，移植细胞的死亡限制了组织再生，寻找新的抗自由基和保护骨髓间充质干细胞的药物有着重要意义。目的：研究芒果苷对体外培养大鼠骨髓间充质干细胞缺氧损伤的保护作用。方法：采用氯化钴(CoCl 2)建立体外培养的大鼠骨髓间充质干细胞缺氧损伤模型。将细胞分为正常对照组、氯化钴缺氧损伤组、氯化钴加芒果苷20，40，80，160µmol/L组。缺氧损伤12，24 h检测各组骨髓间充质干细胞培…查看全部>>
BACKGROUND:Bone marrow mesenchymal stem cells have particularly applied prospects in tissue engineering. However, the death of transplanted cells limits the tissue regeneration. To search a new drug of anti-free radicals and protecting bone marrow mesenchymal stem cells is of great significance. OBJECTIVE:To investigate the protective effects of mangiferin on bone marrow mesenchymal stem cells against hypoxia. METHODS:Rat bone marrow mesenchymal stem cells w…查看全部>>
程建文;赵劲民;李晓峰;谭桢
广西医科大学第一附属医院创伤骨科手外科，广西壮族自治区南宁市 530021广西医科大学第一附属医院创伤骨科手外科，广西壮族自治区南宁市 530021广西医科大学第一附属医院创伤骨科手外科，广西壮族自治区南宁市 530021广西医科大学第一附属医院创伤骨科手外科，广西壮族自治区南宁市 530021
医药卫生
干细胞骨髓干细胞骨髓间充质干细胞芒果苷氧化应激缺氧
bone marrowmesenchymal stem cellsanoxiamangifera
《中国组织工程研究》 2014 (32)
5091-5096,6
广西卫生厅中医药科技专项(GZKZ 10-011)；广西卫生厅中医药科技专项(GZKZ-Z1104)；高等学校博士学科点专项科研基金(20104503110002)；广西科技厅人口健康与食品安全关键技术研究开发项目(桂科攻1140003A-31)；广西卫生厅自筹经费科研课题(桂卫Z2012058，桂卫Z2012061)；广西教育厅立项项目(桂教201010LX050)@@@@the Special Scientific Fund for Traditional Chinese Medicine in Guangxi Health Bureau, No. GZKZ 10-011, GZKZ-Z1104 the Research Fund for the Doctoral Program of Higher Education, No.20104503110002 Key Technology Research and Development Projects of Population Health and Food Safety of Guangxi Science and Technology Bureau, No. guikegong 1140003A-31 Self-Funded Research Projects of Guangxi Health Bureau, No. guiweiZ2012058, guiweiZ2012061 Projects of Guangxi Education Bureau, No. guijiao201010LX050
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