中国组织工程研究Issue(34)：5429-5433,5.DOI:10.3969/j.issn.2095-4344.2014.34.004
生物全降解药物支架植入小型猪冠状动脉：安全性及组织相容性
Safety and histocompatibility of a novel biogradable stent implanted into the coronary artery in a porcine model
卢钊 1黄奕梅 2陈就好 2蒋学俊 1冯高科 1郑晓新 1李君 1秦超师 1顾为望 3王群 2许清如2
作者信息
- 1. 武汉大学人民医院心内科 湖北省武汉市 430060
- 2. 东莞市太平人民医院，广东省东莞市 523905
- 3. 南方医科大学实验动物中心，广东省广州市 510515
- 折叠
摘要
Abstract
BACKGROUND:In order to solve the problems of poly-l-lactic acid (PLLA) stents, such as poor support, acidic metabolites, we researched a novel biogradable stent-PLLA/amorphous calcium plosphate (ACP). <br> OBJECTIVE: To discuss the safety and histocompatibility of the novel biogradable stent-PLLA/ACP stent implanted in the coronary artery in a porcine model. <br> METHODS:Sixteen novel biogradable stents were randomly implanted into the coronary arteries, left anterior descending branch, left circumflex artery or right coronary artery of sixteen healthy Tibet miniature pigs. The blood routine and blood biochemistry were measured pre-operation and at 1 month after operation. The coronary blood vessels where the stent was implanted were examined by hematoxylin-eosin staining at 1 and 6 months after operation. <br> RESULTS AND CONCLUSION: Compared with pre-operation, the post-operation indicators of the blood routine and blood biochemistry were of no significant difference. Coronary angiography revealed coronary artery patency and no thrombosis, the vascular stent segments exhibited clear boundaries with the surrounding tissue, with no tissue adhesion, necrosis, and adherence abnormalities. The results of hematoxylin-eosin staining showed that there was no significant difference in vascular injury integral between 1 month after operation and 6 months after operation. However, 6 months after operation, the scores of the inflammation were lower (P < 0.05), and the scores of the endothelialization were increased (P < 0.05). There was no myocardial infarction and inflammatory cellinfiltration around the stent. These results suggest that the novel biodegradable stent has good safety and histocompatibility.关键词
生物材料/材料相容性/新型生物全降解支架/冠状动脉/组织相容性/安全性/无定型磷酸钙/猪Key words
coronary vessels/calcium phosphates/histocompatibility分类
医药卫生引用本文复制引用
卢钊,黄奕梅,陈就好,蒋学俊,冯高科,郑晓新,李君,秦超师,顾为望,王群,许清如..生物全降解药物支架植入小型猪冠状动脉：安全性及组织相容性[J].中国组织工程研究,2014,(34):5429-5433,5.
