中国组织工程研究Issue(34)：5441-5448,8.DOI:10.3969/j.issn.2095-4344.2014.34.005
珊瑚羟基磷灰石与异体脱细胞真皮基质联合修复牙根尖周组织缺损
Acellular dermal matrix allograft combined with coralline hydroxyapatite repair periapical tissue defects
摘要
Abstract
Chronic periapical periodontitis often causes periapical tissue defects and ultimately leads to the loss of teeth if the inflammation is not promptly cleared to terminate bone resorption and destruction of gingival tissue. Acelular dermal matrix alograft and coraline hydroxyapatite are the common materials to repair periodontal injury. To evaluate clinical efficacy of acelular dermal matrix alograft combined with coraline hydroxyapatite in repairing periapical tissue defects. A total of 76 patients of chronic apical periodontitis were randomly divided into two groups, with 38 cases in each group. In the experimental group, periapical tissue defects were treated with acelular dermal matrix alograft and coraline hydroxyapatite. In the control group, tissue defects were not treated. Al the involved patients underwent apicectomy and retrograde filing. Clinical parameters and radiographic film were recorded at 1 week, 6 months and 3 years folow-up visits to evaluate the repairing effects. After 1 month of treatment, al acelular dermal matrix alografts survived, and the defect of gingival tissues that caused by repairing fistula had been healed. After 3 years, the repairing efficiency in the experimental group was significantly higher than that in the control group (P < 0.05). The bone defect disappeared in the experimental group at 6 months, the transmission of coraline hydroxyapatite particles was decreased, and there were some fuzzy images of compact density. This suggested that new bone was growing. The density of coraline hydroxyapatite particle got closed to normal bone tissue after 3 years, and there were transitional changes of density between coraline hydroxyapatite with normal bone. Coraline hydroxyapatite particle gradualy fused with alveolar bone. Acelular dermal matrix alograft and coraline hydroxyapatite have good biological compatibility. In repairing periapical tissue defects, the application of acelular dermal matrix alograft combined with coraline hydroxyapatite is effective in clinical practice.关键词
生物材料/口腔生物材料/脱细胞真皮基质移植/珊瑚羟基磷灰石/根尖周组织缺损/根尖切除/根尖倒充/慢性根尖周炎/组织再生Key words
hydroxyapatites/periapical periodontitis/periodontitis/periodontium分类
医药卫生引用本文复制引用
徐隽,王进涛,李刚,史芳川,钟良军..珊瑚羟基磷灰石与异体脱细胞真皮基质联合修复牙根尖周组织缺损[J].中国组织工程研究,2014,(34):5441-5448,8.基金项目
新疆维吾尔自治区科技支疆项目(201091144)Funding：a grant from Xinjiang Uygur Autonomous Region, No.201091144 （201091144）
