中国组织工程研究Issue(37)：6040-6045,6.DOI:10.3969/j.issn.2095-4344.2014.37.025
Hedgehog信号调控骨髓间充质干细胞成软骨细胞分化：调控方式及其串话机制尚待研究
Hedgehog signal regulates the chondrogenesis from bone marrow mesenchymal stem cells:controlling methods and cross-talking relationship with other signals need further studies
摘要
Abstract
BACKGROUND:The hedgehog pathway has paid an important role in the progress of chondrogenesis from bone marrow mesenchymal stem cells. However, the definite signal transduction pathway and cross-talking relationship with other common signal pathways are stil poorly understood and the researches related to this field is to continue as a hotspot in the future study. OBJECTIVE:To investigate the research progress of hedgehog signal pathway on the regulation of the chondrogenesis from bone marrow mesenchymal stem cells and the relationship between hedgehog and other signal pathways in the process. METHODS:A computer-based online search in CNKI, PubMed and Google Scholar databases was performed using key words of“Hedgehog, IHH, SHH, bone marrow mesenchymal stem cells, cartilage, chondrogenesis”in English and Chinese, respectively. Literatures related to the process of chondrogenesis from bone marrow mesenchymal stem cells were included and 36 articles were extensively summarized for review. RESULTS AND CONCLUSION:Bone marrow mesenchymal stem cells are currently accepted optimal cellseeds for the cartilage tissue engineering, and hedgehog is a critical signal molecule in the development of skeletal system. The IHH and SHH in hedgehog signal closely participate in control ing the processes of bone marrow mesenchymal stem cellproliferation and chondrogenesis, chondrocyte phenotype maintenance and cooperation with other common single pathways. However, the specific signal transduction mechanism and cross-talking contact with other signal pathways stil need to be further studied, and it stands for the future research directions.关键词
干细胞/骨髓干细胞/软骨/骨髓间充质干细胞/hedgehog/组织工程/国家自然科学基金Key words
bone marrow/mesenchymal stem cells/cartilage/Hedgehog proteins分类
医药卫生引用本文复制引用
刘宽,吴兴..Hedgehog信号调控骨髓间充质干细胞成软骨细胞分化：调控方式及其串话机制尚待研究[J].中国组织工程研究,2014,(37):6040-6045,6.基金项目
国家自然科学基金(81371950) （81371950）
