中国组织工程研究Issue(39)：6233-6239,7.DOI:10.3969/j.issn.2095-4344.2014.39.001
不同植骨材料重建伤椎修复胸腰椎爆裂骨折：验证植骨愈合
Rebuilding injured vertebrae by different kinds of bone graft materials to treat thoracoiumbar burst fractures:an imaging verification of bone healing
史晓林 1刘清阁 1张昊 1田跃 1杨永明 1袁伟东1
作者信息
- 1. 保定市第二医院骨科，河北省保定市 071000
- 折叠
摘要
Abstract
BACKGROUND:Intravertebral bone graft to rebuild anterior and middle column structure and to recover vertebral morphology has been re-understood, and a suitable bone graft material can promote bone healing and be conducive to rebuild the long-term stability of the spine. OBJECTIVE:To discuss the differences in clinical efficacy of three kinds of bone graft materials through unilateral pedicle to treat thoracolumbar burst fractures. METHODS:Total y 102 thoracolumbar burst fracture patients were randomized into three groups:autologous bone, autologous bone combined with al ogeneic bone and al ogeneic bone were implanted via the unilateral pedicle, respectively, in the three groups. We measured the percentage of height of the anterior edge of vertebral body and Cobb angle by X-Ray before and after bone grafting, and used CT to observe bone graft healing, and used Mimics to measure the defect area of vertebral body at the last fol ow-up. RESULTS AND CONCLUSION:Al the 102 patients were fol owed-up for 24-36 months. The percentage of height of the anterior edge of vertebral body and Cobb angle of three groups were restored after bone grafting (P<0.05), but there was no difference in the percentage of height of the anterior edge of vertebral body of three groups at different time point after bone grafting. The Cobb angle in the al ogeneic bone group was bigger than that in the autologous bone group and autologous bone combined with al ogeneic bone group at 9, 12 and 24 months after bone grafting (P<0.05). The fracture healing rate of the al ogeneic bone group at different time points was lower than that of the autologous bone group and autologous bone combined with al ogeneic bone group (P<0.05), and the area of bone defect was bigger than that in the autologous bone group and autologous bone combined with al ogeneic bone group (P<0.05). These findings indicate that these three bone graft materials can rebuild the vertebral body via the unilateral pedicle to treat thoracolumbar burst fracture, reduce the loss of vertebral height and Cobb angle, and decrease defect area of the vertebral body. The clinical efficacy of autologous bone combined with al ogeneic bone to heal bone graft and reduce bone defect is similar to autologous bone, both of which are better than al ogeneic bone alone.关键词
生物材料/骨生物材料/骨缺损/重建椎体/自体骨/同种异体骨移植/胸腰椎爆裂骨折/影像学/对比研究Key words
biocompatible materials/fractures/bone transplantation分类
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史晓林,刘清阁,张昊,田跃,杨永明,袁伟东..不同植骨材料重建伤椎修复胸腰椎爆裂骨折：验证植骨愈合[J].中国组织工程研究,2014,(39):6233-6239,7.
