中国组织工程研究Issue(39)：6353-6358,6.DOI:10.3969/j.issn.2095-4344.2014.39.021
无定形磷酸钙应用在生物医学中的特点
Characteristics of amorphous calcium phosphate in biomedicine
秦超师 1冯高科 1蒋学俊 1李晓艳1
作者信息
- 1. 武汉大学人民医院心内科，湖北省武汉市 430060
- 折叠
摘要
Abstract
BACKGROUND:With good biocompatibility, bioactivity, control able biodegradation rate, amorphous calcium phosphate is considered as a natural reservoir of calcium and phosphorus, which has been widely used in the biomedical field. OBJECTIVE:To review the latest progress of amorphous calcium phosphate in biomedicine based on its clinical application and characteristics. METHODS:A computer-based search of CNKI, Wanfang database and PubMed database from January 1980 to June 2014 was performed for articles relevant to amorphous calcium phosphate materials with the key words of“amorphous calcium phosphate, biomaterials”in Chinese and English. RESULTS AND CONCLUSION:Amorphous calcium phosphate has been widely used in orthodontic care, bone substitutes, drug delivery material and stents, but it is stil in the developmental stage for the special low differentiated cells, cytokines, targeted drug delivery materials and new biodegradable coronary stent. Based on amorphous calcium phosphate, there are various possible treatments for human diseases. But we cannot blindly exaggerate its advantages but outweigh its disadvantages. For example, whether it wil increase the formation of dental calculus during prevention of dental caries? Whether it wil promote its adjacent tissue calcification or hardening? And whether there are risks leading to vascular calcification or hardening? The advantages and disadvantages of amorphous calcium phosphate when used in human are stil needed to carry out a large scale and long-time research.关键词
生物材料/材料相容性/无定形磷酸钙/生物矿化/临床应用/综述Key words
calcium phosphates/review/biomedical research分类
医药卫生引用本文复制引用
秦超师,冯高科,蒋学俊,李晓艳..无定形磷酸钙应用在生物医学中的特点[J].中国组织工程研究,2014,(39):6353-6358,6.
