中国组织工程研究Issue(39)：6359-6363,5.DOI:10.3969/j.issn.2095-4344.2014.39.022
胶原及丝素蛋白支架材料在脊髓组织工程中的应用
Application of collagen and silk fibroin scaffolds in spinal cord tissue engineering
摘要
Abstract
BACKGROUND:Col agen and silk fibroin materials for construction of spinal cord scaffolds have been proven to repair or partial y repair damaged spinal cord nerve function. OBJECTIVE:To introduce partial characteristics of the col agen and silk fibroin and to review the recent progress and application as scaffolds in spinal cord tissue engineering. METHODS:A computer-based search of CNKI and PubMed databases (2003-01/2012-10) was performed for articles addressing the application of col agen and silk fibroin scaffolds in spinal cord injury with the keywords of“col agen, silk fibroin, scaffold, spinal cord injury”in Chinese and English, respectively. RESULTS AND CONCLUSION:Col agen has low antigenicity, good biocompatibility and biodegradability. Col agen and its degradation products can cause no inflammatory reactions in the body, but have the disadvantages of rapid degradation and poor mechanical properties. Silk fibroin has good biocompatibility and excellent mechanical properties, but its degradation is slow. The col agen and silk fibroin are compounded using an electrostatic spinning technology to improve the physical properties of the material on the basis of maintaining good biocompatibility. At present, fibroin or col agen materials in terms of nervous system repair have been studied, laying some foundation for spinal cord tissue engineering. Considering the similar characteristics and mechanics performance to the spinal cord tissue, col agen/silk fibroin composite materials are expected to become the ideal scaffold materials for spinal cord tissue engineering.关键词
生物材料/材料相容性/胶原蛋白/丝素蛋白/脊髓损伤/组织工程/国家自然科学基金Key words
col agen/silk/spinal cord injuries分类
医药卫生引用本文复制引用
朱祥,陈旭义,刘英富,邢冉,涂悦..胶原及丝素蛋白支架材料在脊髓组织工程中的应用[J].中国组织工程研究,2014,(39):6359-6363,5.基金项目
天津市科技支撑计划重点项目(14ZCZDGX00500)；国家自然科学基金青年项目(11102235)；天津市自然科学基金重点项目(12JCZDJC24100)；天津市卫生局科技基金项目(2013KZ134)；武警后勤学院附属医院种子基金项目(FYM201432) （14ZCZDGX00500）
