中国组织工程研究Issue(41)：6696-6702,7.DOI:10.3969/j.issn.2095-4344.2014.41.024
脂肪干细胞成骨分化及与复合支架结合：在修复骨质疏松症骨缺损中的应用
Osteogenic differentiation of adipose-derived stem cells on a composite scaffold in the repair of osteoporotic bone defects
摘要
Abstract
BACKGROUND:The traditional treatment methods for osteoporosis accompanied by bone defects, such as autogenous bone graft, al ograft, biomaterial implants, have significant limitations. The regenerative medicine approach using adipose-derived stem cells as seed cells offers a new way for the repair of bone defects fol owing osteoporosis. OBJECTIVE:To review the pathogenesis of osteoporosis and its impacts on the repair of bone defects, the signal pathway regulation of osteogenic differentiation of adipose-derived stem cells, and the feasibility of adipose-derived stem cells for repairing osteoporotic bone defects. METHODS:A computer-based online search of CNKI database and PubMed database was performed to retrieve the relevant articles published from January 1998 to September 2014 with the key words of“adipose-derived stem cells, osteoporosis, bone defect, osteogenic differentiation, bone regeneration”in Chinese and English, respectively. Final y 77 articles were included for review after deleting unrelated and repetitive ones. RESULTS AND CONCLUSION:In recent years, adipose-derived stem cells have been widely used in regenerative medicine research. With the development of relevant disciplines such as regenerative medicine, tissue engineering, molecular biology, and material science, in-depth studies on regulatory mechanisms of osteogenic differentiation of adipose-derived stem cells have been developed. Adipose-derived stem cells combined with biological scaffolds for construction of tissue-engineered bones provides a new way to repair osteoporotic bone defects.关键词
干细胞/脂肪干细胞/骨质疏松症/骨缺损/修复/成骨分化/骨再生/国家自然科学基金Key words
stem cells/adipose tissue/osteoporosis/bone regeneration分类
医药卫生引用本文复制引用
黄成龙,肖金刚..脂肪干细胞成骨分化及与复合支架结合：在修复骨质疏松症骨缺损中的应用[J].中国组织工程研究,2014,(41):6696-6702,7.基金项目
国家自然科学基金项目(81371125)；四川省科技厅项目(2014JY0044)；四川省教育厅项目(10ZB030)；四川省卫生厅项目(80170)；泸州医学院重点项目(201207) （81371125）
