中国组织工程研究Issue(42)：6838-6843,6.DOI:10.3969/j.issn.2095-4344.2014.42.022
运动影响骨转换：促进或抑制骨细胞/破骨细胞的发育和活性
Effects of exercise on bone turnover:promoting or inhibiting development and viability of osteoblasts/osteoclasts
摘要
Abstract
BACKGROUND:Bone turnover markers are the products in the blood or urine in the process of bone reconstruction, which can be used to evaluate bone resorption and bone formation rate, thereby indicating potential bone diseases. OBJECTIVE:To analyze the effect of exercise on the levels of bone turnover markers in the blood and urine samples. METHODS:Databases of PubMed and Wangfang were retrieved with key words of“bone formation, bone resorption, alkaline phosphotase, osteocalcin PICP, PINP, hydroxyproline, pyridinoline, tartrate resistant acid phosphatase”by screening titles and abstracts to search papers related to exercise effects on the biological markers of bone formation. Final y, 48 papers were discussed. RESULTS AND CONCLUSION:The effect of exercise on bone turnover refers to the influence on bone formation and bone resorption. Exercise enhances or inhibits the activity of osteoblasts and osteoclasts, and accelerates or delays bone reconstruction by promoting or inhibiting the growth of osteoblasts and osteoclasts. In recent years, exercise exhibits more and more influence on the bone. Bone turnover markers compared with bone mineral density show changes earlier. By measuring the levels of bone turnover markers in blood and urine samples, it help us to understand the metabolism of bone tissue, to evaluate bone metabolic state, osteoporosis diagnosis classification, predicting of fracture risk, to observe the curative effect of drug treatment, and to diagnosis the metabolic bone differential disease.关键词
组织构建/骨组织工程/骨形成/骨吸收/碱性磷酸酶/骨钙素/前胶原肽(PICP和PINP)/羟脯氨酸/吡啶啉和脱氧吡啶啉/Ⅰ型胶原交联N末端肽(NTX)/Ⅰ型胶原C端肽(CTX)/抗酒石酸酸性磷酸酶/国家自然科学基金Key words
alkaline phosphatase/osteocalcin分类
医药卫生引用本文复制引用
张玲莉,陈炳霖,邹军..运动影响骨转换：促进或抑制骨细胞/破骨细胞的发育和活性[J].中国组织工程研究,2014,(42):6838-6843,6.基金项目
教育部高等学校博士学科点专项科研基金资助课题(20133156110002)；国家自然科学基金项目(81170323)；“上海市人类运动能力开发与保障重点实验室(上海体育学院)(11DZ2261100)”资助 （20133156110002）
