中国组织工程研究Issue(44)：7077-7082,6.DOI:10.3969/j.issn.2095-4344.2014.44.05
胫骨平台及踝部骨折内外固定后低毒性感染伴窦道形成：口服利福平、环丙沙星加皮瓣移植修复的效果
Hypotoxicity infection with sinus formation after tibial plateau and ankle fracture fixation:effects of orally taking rifampicin and ciprofloxacin with transfer of skin flap
摘要
Abstract
BACKGROUND:Recently, there are many documents al over the world reporting hypotoxicity infection after fracture internal fixation surgery, but reports are different on whether it is necessary for chronic hypotoxicity infection internal fixation removal post surgery. There are no fixed judgment criteria of curative effects, which leads to inexact conclusion of treatment method. <br> OBJECTIVE:To observe the curative effects of taking rifampicin and ciprofloxacin with transfer of skin flap in the treatment of chronic hypotoxicity infection with sinus formation after fracture surgery on tibial plateau and ankle. METHODS:A total of 56 cases of chronic hypotoxicity infection after fracture surgery of tibial plateau and ankle were col ected from September 2005 to December 2012. 30 cases in the therapy group were treated with <br> levofloxacin and rifampicin with transfer of skin flap. 26 cases in the control group were treated with conventional intravenous antibiotics with local debridement to remove internal fixation. In both groups, the course of disease was 3 to 6 months. The erythrocyte sedimentation rate, kidney function and radiographic indices were reviewed every 1 to 3 months, and curative effects were evaluated. <br> RESULTS AND CONCLUSION:During the fol ow-up visit of 6-24 months, no recurrence happened to the cured and improved patients. In the therapy group, 24 cases were cured, 4 cases were improved, and 2 cases were invalid, with a total effective rate of 93%. In the control group, 11 cases were cured, 6 cases were improved and 9 cases were invalid with the total effective rate of 65%.χ2 test showed that therapeutic effects were significantly better in the therapy group than in the control group (P<0.05). These data indicated that rifampicin and ciprofloxacin with transfer of skin flap for chronic hypotoxicity infection with sinus formation after fracture surgery of tibial plateau and ankle showed good curative effects.关键词
植入物/骨植入物/低毒性感染/窦道形成/骨折术后/利福平/环丙沙星/皮瓣转移/治疗分类
医药卫生引用本文复制引用
张波,杨立峰,刘丰虎,杨斌辉,赵金龙,欧阳振,于洋,吴涛,宋永才,李伍健,刘继超,尹伟..胫骨平台及踝部骨折内外固定后低毒性感染伴窦道形成：口服利福平、环丙沙星加皮瓣移植修复的效果[J].中国组织工程研究,2014,(44):7077-7082,6.基金项目
汉中市科技发展计划基金(2011(二)13)Funding:the Hanzhong Municipal Science and Technology Development Fund, No.2011(2)13 （2011(二）
